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Titolo:
Morning versus evening administration of estradiol to girls with Turner syndrome receiving growth hormone: impact on growth hormone and metabolism. Arandomized placebo-controlled crossover study
Autore:
Naeraa, RW; Gravholt, CH; Kastrup, KW; Svenstrup, B; Christiansen, JS;
Indirizzi:
Aarhus Univ Hosp, Dept Pediat, Skejby Sygehus, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N jby Sygehus, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp, Aarhus Kommune Hosp, Med Dept M, DK-8000 Aarhus, DenmarkAarhus Univ Hosp Aarhus Denmark DK-8000 Dept M, DK-8000 Aarhus, Denmark Aarhus Univ Hosp, Aarhus Kommune Hosp, Med Res Labs, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 es Labs, DK-8000 Aarhus, Denmark Copenhagen County Hosp, Dept Pediat, Glostrup, Denmark Copenhagen County Hosp Glostrup Denmark Dept Pediat, Glostrup, Denmark Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark StatensSerum Inst Copenhagen Denmark DK-2300 K-2300 Copenhagen, Denmark
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 5, volume: 90, anno: 2001,
pagine: 526 - 531
SICI:
0803-5253(200105)90:5<526:MVEAOE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN REPLACEMENT THERAPY; GH-DEFICIENT PATIENTS; INSULIN RESISTANCE; BINDING-PROTEIN; ETHINYL ESTRADIOL; SOMATOMEDIN-C; FACTOR-I; POSTMENOPAUSAL WOMEN; GONADAL-DYSGENESIS; GLUCOSE-METABOLISM;
Keywords:
17 beta-estradiol; GH; IGF-I; insulin resistance; Turner syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Naeraa, RW Aarhus Univ Hosp, Dept Pediat, Skejby Sygehus, DK-8200 Aarhus N, Denmark Aarhus Univ Hosp Aarhus Denmark N , DK-8200 Aarhus N, Denmark
Citazione:
R.W. Naeraa et al., "Morning versus evening administration of estradiol to girls with Turner syndrome receiving growth hormone: impact on growth hormone and metabolism. Arandomized placebo-controlled crossover study", ACT PAEDIAT, 90(5), 2001, pp. 526-531

Abstract

Timing of 17 beta -estradiol (E2) administration in relation to that of GHcould influence the "first pass effect" of E2 on hepatic IGF-1 secretion. In order to test this hypothesis, a randomized double-blind placebo-controlled crossover study was conducted. Nine Turner girls (12,8-20.0 y) were treated for 2 mo periods with GH 0.1 IU/kg/d sc at bedtime, and oral E2 6-11 mug/kg/d in the morning and placebo in the evening in one 2-mo period and vice versa in the other period. After each period, 24-h blood sampling was performed. IGF-1 and mean 24-h integrated GH were comparable. However, the IGF-1/IGFBP-3 ratio was higher (p = 0.05) and insulin levels were lower afterevening administration of E2 (24 h: p, = 0.03). During an oral glucose tolerance test in the morning, glucagon and insulin were lower following evening E2 administration (ANOVA: glucagon, p = 0.03; insulin, p = 0.04), as well as insulin resistance tended to be lower (p, = 0.09). Conclusion: The timing of oral E2 supplementation modulates the IGF-I/IGFBP-3 ratio, insulin and glucagon levels in Turner syndrome during GH treatment. Evening administration of oral estrogen together with evening injections of GH may be preferable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:54:34