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Titolo:
Additive IOP-reducing effect of latanoprost in patients insufficiently controlled on timolol
Autore:
Bron, AM; Denis, P; Nordmann, JP; Rouland, JF; Sellem, E; Johansson, M;
Indirizzi:
Hop Gen Dijon, Dept Ophthalmol, Serv Ophtalmol, F-21000 Dijon, France Hop Gen Dijon Dijon France F-21000 Serv Ophtalmol, F-21000 Dijon, France Hop Edouard Herriot, Serv Ophtalmol, Lyon, France Hop Edouard Herriot Lyon France d Herriot, Serv Ophtalmol, Lyon, France Serv Ophtalmol, Paris, France Serv Ophtalmol Paris FranceServ Ophtalmol, Paris, France Ctr Hosp Reg & Univ Lille, Hop Huriez, Serv Ophtalmol, F-59037 Lille 31, France Ctr Hosp Reg & Univ Lille Lille France 31 lmol, F-59037 Lille 31, France Ctr Ophtalmol, Lyon, France Ctr Ophtalmol Lyon FranceCtr Ophtalmol, Lyon, France Pharmacia & Upjohn AB, Uppsala, Sweden Pharmacia & Upjohn AB Uppsala Sweden macia & Upjohn AB, Uppsala, Sweden
Titolo Testata:
ACTA OPHTHALMOLOGICA SCANDINAVICA
fascicolo: 3, volume: 79, anno: 2001,
pagine: 289 - 293
SICI:
1395-3907(200106)79:3<289:AIEOLI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-ANGLE GLAUCOMA; OCULAR HYPERTENSION; INTRAOCULAR-PRESSURE; PROSTAGLANDIN-F2-ALPHA ANALOG; UVEOSCLERAL OUTFLOW; HUMAN EYES; PHXA41; HYPOTENSION; DYNAMICS; 6-MONTH;
Keywords:
latanoprost; timolol; additivity; switch; open angle glaucoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Bron, AM Hop Gen Dijon, Dept Ophthalmol, Serv Ophtalmol, 3 Rue Faubourg Raines, F-21000 Dijon, France Hop Gen Dijon 3 Rue Faubourg Raines Dijon France F-21000 France
Citazione:
A.M. Bron et al., "Additive IOP-reducing effect of latanoprost in patients insufficiently controlled on timolol", ACT OPHTH S, 79(3), 2001, pp. 289-293

Abstract

Purpose: To evaluate the effect on intraocular pressure (IOP) of switchingfrom timolol to latanoprost or adding latanoprost to timolol in patients with open angle glaucoma or ocular hypertension where IOP is not adequately controlled with timolol,Methods: This was a 6-week, double-masked, randomised multi-centre study 53 patients with primary open angle glaucoma, capsular glaucoma, or ocular hypertension with an IOP of at least 21 mmHg on current therapy were recruited. After a run-in period of at least 2 weeks on timolol, 5 mg/ml twice daily, patients were randomised to one of three groups. One group continued ontimolol, one switched from timolol to latanoprost, 50 mug/ml once daily, and a third group received latanoprost in addition to timolol, The efficacy was evaluated by comparing IOP at 9 AM at baseline and after 6 weeks of treatment. Results: IOP at baseline and after 6 weeks of treatment (mean +/- SEM) were 24.2 +/- 0.9 and 23.8 +/- 1.0 mmHg (n = 16) for patients continuing on timolol, 26.3 +/- 1.2 and 19.6 +/- 1.1 mmHg (n = 17) for patients switching to latanoprost, and 23.2 +/- 1.0 and 17.5 +/- 0.8 mmHg (n = 17) for patientswith combined treatment. Adding latanoprost to timolol reduced IOP with 5.9 +/- 0.9 mmHg (p < 0.001) and switching from timolol to latanoprost reduced IOP with 5.0 +/- 0.9 mmHg (p < 0.001), which caused in each group a significant IOP reduction of about 25%. Conclusions: The effect of latanoprost was additive to that of timolol, and a good effect on IOP reduction was also achieved by switching from timolol to latanoprost, suggesting that a switch in many patients is an effectivealternative to combination treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:39:00