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Titolo:
Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells
Autore:
Hata, A; Zerboni, L; Sommer, M; Kaspar, AA; Clayberger, C; Krensky, AM; Arvin, AM;
Indirizzi:
Stanford Univ, Sch Med, Div Infect Dis, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iv Infect Dis, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Pediat, Div Immunol & Transplantat Biol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 splantat Biol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Cardiothorac Surg, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iothorac Surg, Stanford, CA 94305 USA
Titolo Testata:
VIRAL IMMUNOLOGY
fascicolo: 2, volume: 14, anno: 2001,
pagine: 125 - 133
SICI:
0882-8245(2001)14:2<125:GBROVV>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Arvin, AM Stanford Univ, Sch Med, Div Infect Dis, G311, Stanford, CA 94305USA Stanford Univ G311 Stanford CA USA 94305 Stanford, CA 94305 USA
Citazione:
A. Hata et al., "Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells", VIRAL IMMUN, 14(2), 2001, pp. 125-133

Abstract

Granulysin, a lytic protein present in cytolytic granules of human naturalkiller and cytotoxic T cells, entered cells infected with varicella-zostervirus (VZV), Exposure to granulysin accelerated death of infected cells asassessed by apoptosis markers. The functional domain of granulysin that mediated its antiviral effects was amino acid 23-51; this domain also mediates the additional antitumor cell effects of granulysin, Because granulysin is a product of natural killer cells and T lymphocytes, it is possible that its antiviral activity may act as a mediator of innate and adaptive immune mechanisms.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:29:17