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Titolo:
Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis
Autore:
Keay, SK; Zhang, CO; Shoenfelt, J; Erickson, DR; Whitmore, K; Warren, JW; Marvel, R; Chai, T;
Indirizzi:
Univ Maryland, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Infect Dis, Baltimore, MD 21201 USA Dept Vet Affairs Med Ctr, Res Serv, Baltimore, MD USA Dept Vet Affairs MedCtr Baltimore MD USA r, Res Serv, Baltimore, MD USA Penn State Univ, Coll Med, Dept Surg, Urol Sect, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 rg, Urol Sect, Hershey, PA 17033 USA Med Coll Penn & Hahnemann Univ, Med Ctr, Dept Urol, Philadelphia, PA 19102USA Med Coll Penn & Hahnemann Univ Philadelphia PA USA 19102 hia, PA 19102USA Giv Gen Obstet & Gynecol, Baltimore, MD USA Giv Gen Obstet & Gynecol Baltimore MD USA t & Gynecol, Baltimore, MD USA Univ Maryland, Sch Med, Dept Surg, Div Urol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 g, Div Urol, Baltimore, MD 21201 USA
Titolo Testata:
UROLOGY
fascicolo: 6A, volume: 57, anno: 2001, supplemento:, S
pagine: 9 - 14
SICI:
0090-4295(200106)57:6A<9:SASOAF>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAINFUL BLADDER DISEASE; HUMAN UROTHELIAL CELLS; EPITHELIAL-CELLS; IN-VITRO; GLYCOPROTEIN; ACTIVATION; KALLIKREIN; EXCRETION; TRYPTASE; SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Keay, SK Vet Adm Med Ctr, Room 3B-184,10 N Greene St, Baltimore, MD 21201 USA Vet Adm Med Ctr Room 3B-184,10 N Greene St Baltimore MD USA 21201
Citazione:
S.K. Keay et al., "Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis", UROLOGY, 57(6A), 2001, pp. 9-14

Abstract

We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-ECF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis. We sought to confirm the specificity of these findings for IC using a larger patient population, including control patients with a varietyof urogenital disorders. Clean catch urine specimens were collected from 219 symptomatic IC patients, 113 asymptomatic controls without bladder disease. and 211 patients with various urogenital diseases including acute bacterial cystitis, vulvovaginitis, chronic nonbacterial prostatitis, overactivebladder, hematuria, stress incontinence, neurogenic bladder. benign prostatic hyperplasia, bladder or pelvic pain without voiding symptoms, bladder cancer, prostate cancer, or miscellaneous diagnoses including anatomic disorders. APF activity was determined by H-3-thymidine incorporation into primary normal adult human bladder epithelial cells. HB-EGF and EGF levels were determined by enzyme-linked immunosorbent assay. APF activity was present significantly more often in IC than control urine specimens (P <0.005 for ICvs any control group; sensitivity = 94%, specificity = 95%, P < 10(-82) for IC vs all controls). HB-EGF levels were also significantly lower and EGF levels significantly higher in IC urine than in specimens from controls (P < 10(-84) and p < 10(-36), respectively). These findings confirm the utility of APF, HB-EGF, and EGF as markers for IC. Understanding the reasons for altered levels of these markers may lead to understanding the pathogenesis of this disorder. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:52:50