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Titolo:
Reassuring effect of pravastatin on natural killer cell activity in stablerenal transplant patients
Autore:
Vaessen, LMB; van Miert, PPMC; van Gelder, T; IJzermans, JNM; Weimar, W;
Indirizzi:
Univ Rotterdam, Hosp Rotterdam Dijkzigt, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands Univ Rotterdam Rotterdam Netherlands NL-3000 CA A Rotterdam, Netherlands Univ Rotterdam, Hosp Rotterdam Dijkzigt, Dept Surg, NL-3000 CA Rotterdam, Netherlands Univ Rotterdam Rotterdam Netherlands NL-3000 CA A Rotterdam, Netherlands
Titolo Testata:
TRANSPLANTATION
fascicolo: 8, volume: 71, anno: 2001,
pagine: 1175 - 1179
SICI:
0041-1337(20010427)71:8<1175:REOPON>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HMG-COA REDUCTASE; IMMUNOLOGICAL PARAMETERS; CYCLOSPORINE-A; CYTO-TOXICITY; IN-VITRO; RECIPIENTS; AZATHIOPRINE; HYPERLIPIDEMIA; INHIBITORS; CONVERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Vaessen, LMB Univ Rotterdam, Hosp Rotterdam Dijkzigt, Dept Internal Med, POB 2040,Bd299, NL-3000 CA Rotterdam, Netherlands Univ Rotterdam POB 2040,Bd299 Rotterdam Netherlands NL-3000 CA
Citazione:
L.M.B. Vaessen et al., "Reassuring effect of pravastatin on natural killer cell activity in stablerenal transplant patients", TRANSPLANT, 71(8), 2001, pp. 1175-1179

Abstract

Background. Administration of pravastatin soon after transplantation successfully lowers cholesterol levels, whereas a reduced number of acute rejection episodes is accompanied by a decrease in natural killer (NK) cell activity, As a consistent low NK cell activity caused by pravastatin might impair tumor surveillance leading to cancer, we studied the effect of pravastatin on NK cell activity in stable renal transplant patients. Methods, From 14 cyclosporine (CsA) treated and 11 azathioprine (AZA)-treated patients with hypercholesterolemia, more than 1 year after kidney transplantation, we determined NK cell number and cytotoxic activity before, andat 6 and 12 weeks after, initiating pravastatin treatment, Additionally, cholesterol levels and liver and kidney function parameters were assessed. Results. During pravastatin treatment, total cholesterol and low-density lipoprotein cholesterol levels decreased significantly in both patient groups, In the CsA group, the number and cytotoxic activity of the NK cells at 12 weeks after institution of pravastatin was in the same range as before pravastatin, Additionally, in the AZA group, pravastatin did not influence the number of NK cells. However, in the AZA group, both the number of NK cells and their cytotoxic activity were significantly (<0.002) lower compared to the values in the CsA group. Conclusions, In contrast to previous reports on decreased NK cell cytotoxicity caused by pravastatin treatment early after transplantation, we cannotconfirm these results in stable kidney recipients. In our hands, Mt cell cytotoxicity during pravastatin treatment was within the same range as in the absence of pravastatin. Thus, in view of the potential role of NK cells in tumor surveillance, these data are reassuring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:07:27