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Titolo:
Saliva as an alternative body fluid for therapeutic drug monitoring of thenonnucleoside reverse transcription inhibitor nevirapine
Autore:
van Heeswijk, RPG; Veldkamp, AI; Mulder, JW; Meenhorst, PL; Beijnen, JH; Lange, JMA; Hoetelmans, RMW;
Indirizzi:
Slotervaart Hosp, Dept Pharm & Pharmacol, Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands harmacol, Amsterdam, Netherlands Slotervaart Hosp, Dept Internal Med, Amsterdam, Netherlands Slotervaart Hosp Amsterdam Netherlands rnal Med, Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Natl AIDS Therapy Evaluat Ctr, NL-1100 DE Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 DE E Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1100 DE Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1100 DE E Amsterdam, Netherlands
Titolo Testata:
THERAPEUTIC DRUG MONITORING
fascicolo: 3, volume: 23, anno: 2001,
pagine: 255 - 258
SICI:
0163-4356(200106)23:3<255:SAAABF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE; PATIENT; PLASMA;
Keywords:
HIV; nevirapine; pharmacokinetics; saliva; therapeutic drug monitoring;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: van Heeswijk, RPG Univ Amsterdam, Acad Med Ctr, Int Antiviral Therapy Evaluat Ctr, Meibergdreef 9,POB 22700, NL-1100 DE Amsterdam, Netherlands Univ Amsterdam Meibergdreef 9,POB 22700 Amsterdam Netherlands NL-1100 DE
Citazione:
R.P.G. van Heeswijk et al., "Saliva as an alternative body fluid for therapeutic drug monitoring of thenonnucleoside reverse transcription inhibitor nevirapine", THER DRUG M, 23(3), 2001, pp. 255-258

Abstract

The objective of this study was to evaluate the applicability of saliva asan alternative body fluid for therapeutic drug monitoring of nevirapine. The pharmacokinetics of nevirapine in plasma and saliva during a dosing interval was assessed in HIV-1-infected patients taking nevirapine (200 mg twice daily) to explore the relation between the concentration of nevirapine inplasma and saliva. To validate the anticipated relationship prospectively,single, paired plasma and saliva samples were obtained from nevirapine-treated HIV-1-infected outpatients. The plasma nevirapine concentration was strongly correlated with the salivary concentration. The mean saliva/plasma concentration ratio was 0.51 and was independent of the time after ingestion. Salivary nevirapine concentrations were used to estimate the corresponding plasma concentrations for 31 outpatients. Compared with the true plasma concentrations, the estimated concentrations were biased by -4.2%, with a precision of 13.3%. These data show a strong correlation between the salivaryand plasma concentrations of nevirapine at a dosage of 200 mg twice daily. This relation has been validated prospectively, and the prediction of plasma concentrations was accurate and precise. Therefore, the authors concludethat saliva can be a useful body fluid for therapeutic drug monitoring of nevirapine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:35:46