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Titolo:
Tonic opioid inhibition of the subiculo-accumbens pathway
Autore:
Hakan, RL;
Indirizzi:
Univ N Carolina, Dept Psychol, Wilmington, NC 28401 USA Univ N Carolina Wilmington NC USA 28401 Psychol, Wilmington, NC 28401 USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 41, anno: 2001,
pagine: 71 - 85
SICI:
0887-4476(200107)41:1<71:TOIOTS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; VENTRAL TEGMENTAL AREA; PHASEOLUS-VULGARIS LEUCOAGGLUTININ; FREELY MOVING RATS; HIPPOCAMPAL-FORMATION; PREFRONTAL CORTEX; DOPAMINE SYSTEMS; CATECHOLAMINERGIC TERMINALS; TOPOGRAPHICAL ORGANIZATION; 6-HYDROXYDOPAMINE LESIONS;
Keywords:
accumbens; opiates; naloxone; evoked response; subiculum; medium spiny neurons; electrophysiology; micro-iontophoresis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
131
Recensione:
Indirizzi per estratti:
Indirizzo: Hakan, RL Univ N Carolina, Dept Psychol, 601 S Coll Rd, Wilmington, NC 28401 USA Univ N Carolina 601 S Coll Rd Wilmington NC USA 28401 28401 USA
Citazione:
R.L. Hakan, "Tonic opioid inhibition of the subiculo-accumbens pathway", SYNAPSE, 41(1), 2001, pp. 71-85

Abstract

There is evidence to suggest that medium spiny neurons (MSNs) in the nucleus accumbens (NAS) should be sensitive to opiate compounds. However, neuronal responses in the NAS evoked by fimbria stimulation (F-D) are insensitiveto systemically or iontophoretically administered morphine. The hypothesisof this study was that fimbria-evoked NAS responses may fail to demonstrate sensitivity to morphine because they are under tonic opioid inhibition and can't be further inhibited by opiates. If correct, then pharmacological inhibition of opioid actions on these NAS neuronal responses should result in an increase of response to fimbria stimulation. The effects of systemic and iontophoretic administrations of naloxone on NAS responses evoked by fimbria stimulation were observed. Systemically and locally administered naloxone selectively increased the excitability of accumbens single-unit responses to fimbria stimulation. Conversely, systemic or iontophoretic administration of morphine was without effect on the same types of NAS responses. These observations are consistent with the hypothesis that a tonic opioid inhibition may regulate this pathway. In contrast, naloxone and morphine effectother NAS circuit responses differently than F-D NAS responses. In some cases naloxone and morphine tests have been conducted on different evoked responses from the same neuron. Those results have shown that different responses from the same cell may be differentially affected. Consequently, opioidmodulation of activity in the NAS is probably pathway-specific rather thanneuron-specific. Synapse 41:71-85, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 15:16:08