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Titolo:
Changes in hippocampal adenosine efflux, ATP levels, and synaptic transmission induced by increased temperature
Autore:
Masino, SA; Latini, S; Bordoni, F; Pedata, F; Dunwiddie, TV;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Dept Pharmacol, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Neurosci Program, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Neurosci Program, Denver, CO 80262 USA Univ Florence, Dept Preclin & Clin Pharmacol, Florence, Italy Univ Florence Florence Italy Preclin & Clin Pharmacol, Florence, Italy Vet Affairs Med Res Serv, Denver, CO USA Vet Affairs Med Res Serv Denver CO USA airs Med Res Serv, Denver, CO USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 41, anno: 2001,
pagine: 58 - 64
SICI:
0887-4476(200107)41:1<58:CIHAEA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-LIKE CONDITIONS; RAT HIPPOCAMPUS; GUINEA-PIG; EXTRACELLULAR ADENOSINE; ELECTRICAL-STIMULATION; SLICES; RELEASE; INHIBITION; HYPOXIA; OUTFLOW;
Keywords:
adenosine; adenosine receptors; hippocampus; hypoxia; hyperthermia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Masino, SA Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, 4200 E 9th Ave, Denver, CO 80262 USA Univ Colorado 4200 E 9th Ave Denver CO USA 80262 , CO 80262 USA
Citazione:
S.A. Masino et al., "Changes in hippocampal adenosine efflux, ATP levels, and synaptic transmission induced by increased temperature", SYNAPSE, 41(1), 2001, pp. 58-64

Abstract

Previous studies have demonstrated that when the temperature of hippocampal brain slices is increased, there is a corresponding depression of synaptic potentials mediated by an increased activation of presynaptic adenosine A, receptors. The present experiments demonstrate that when the temperature of hippocampal slices is raised from 32.5 degreesC to either 38.5 degreesC or 40.0 degreesC there is a marked, temperature-dependent increase in the efflux of endogenous adenosine and a corresponding decrease in excitatory synaptic responses. The increase in efflux is rapidly reversible on lowering the slice temperature and the temperature-induced efflux is repeatable. Control experiments suggest that this increased efflux of adenosine is not theresult of hypoxia or ischemia secondary to a temperature-induced increase in the metabolic rate of the slice. The increase in adenosine efflux was not accompanied by any significant change in the ATP levels in the brain slice, whereas a hypoxic stimulus sufficient to produce a comparable depressionof excitatory transmission produced an similar to 75% decrease in ATP levels. These experiments indicate that changes in brain slice temperature can alter purine metabolism in such a way as to increase the adenosine concentration in the extracellular space, as well as adenosine efflux from hippocampal slices, in the absence of significant changes in ATP levels. Synapse 41:58-64, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:47:00