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Titolo:
Sensitivity of synaptic GABA(A) receptors to allosteric modulators in hippocampal oriens-alveus interneurons
Autore:
Patenaude, C; Nurse, S; Lacaille, JC;
Indirizzi:
Univ Montreal, Fac Med, Dept Physiol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada Univ Montreal, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 41, anno: 2001,
pagine: 29 - 39
SICI:
0887-4476(200107)41:1<29:SOSGRT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA1 PYRAMIDAL CELLS; AMINOBUTYRIC ACID(A) RECEPTORS; SUBUNIT MESSENGER-RNAS; TEMPORAL-LOBE EPILEPSY; RAT HIPPOCAMPUS; A RECEPTOR; GABA(A)-RECEPTOR SUBTYPES; POSTNATAL-DEVELOPMENT; ALPHA-4 SUBUNIT; GRANULE CELLS;
Keywords:
hippocampus; mIPSCs; inhibitory synapses; benzodiazepines; GABA(A); receptor configuration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Lacaille, JC Univ Montreal, Fac Med, Dept Physiol, CP 6128,Succ Ctr Ville,Montreal, PQH3C 3J7, Canada Univ Montreal CP 6128,Succ Ctr Ville Montreal PQ Canada H3C 3J7
Citazione:
C. Patenaude et al., "Sensitivity of synaptic GABA(A) receptors to allosteric modulators in hippocampal oriens-alveus interneurons", SYNAPSE, 41(1), 2001, pp. 29-39

Abstract

GABA(A) receptors are heteropentamers that are heterogeneously distributedat different synapses in the central nervous system. Although the modulation of GABA(A) receptors received much attention in hippocampal pyramidal cells, information is scarce regarding the pharmacology of these receptors ininhibitory interneurons. We investigated the pharmacological properties ofGABA(A)-mediated miniature inhibitory postsynaptic currents (mIPSCs) usingwhole-cell voltage clamp recordings in two morphologically identified types of hippocampal CA1 interneurons, horizontal and vertical cells of stratumoriens-alveus. The negative modulators zinc (200 muM) and furosemide (600 muM) significantly decreased the amplitude of mIPSCs. Benzodiazepine agonists also produced significant effects: 10 muM zolpidem increased the amplitude, rise time, and decay time constant (decay tau) of mIPSCs, whereas 10 muM flunitrazepam affected similarly the amplitude and decay tau, but not therise time. The neurosteroid allopregnanolone (10 muM) prolonged the decay tau of mIPSCs. Since these modulators act on different GABA(A) receptor subunits, this pharmacological profile suggests that GABA(A) receptors at spontaneously active inhibitory synapses onto vertical and horizontal interneurons are heterogeneous and formed by coassembly of different combinations ofsubunits (alpha (1-5)beta (1-3)gamma (1-3)). Furthermore, these synaptic GABA(A) receptors appear in large part pharmacologically similar to those ofpyramidal cells. Synapse 41:29-39, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:28:07