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Titolo:
Expression and acquisition of the conditioned place preference response tococaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADase)
Autore:
Slusher, BS; Thomas, A; Paul, M; Schad, CA; Ashby, CR;
Indirizzi:
St Johns Univ, Coll Pharm & Allied Hlth Profess, PHS Dept, Jamaica, NY 11439 USA St Johns Univ Jamaica NY USA 11439 ofess, PHS Dept, Jamaica, NY 11439 USA Guilford Pharmaceut Inc, Dept Res, Baltimore, MD USA Guilford Pharmaceut Inc Baltimore MD USA nc, Dept Res, Baltimore, MD USA Eon Labs Mfg Inc, Laurelton, NY USA Eon Labs Mfg Inc Laurelton NY USAEon Labs Mfg Inc, Laurelton, NY USA
Titolo Testata:
SYNAPSE
fascicolo: 1, volume: 41, anno: 2001,
pagine: 22 - 28
SICI:
0887-4476(200107)41:1<22:EAAOTC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPARTATE RECEPTOR ANTAGONISTS; NUCLEUS-ACCUMBENS; SEEKING BEHAVIOR; GLUTAMATE TRANSMISSION; MK-801 DIZOCILPINE; NMDA ANTAGONIST; NERVOUS-SYSTEM; BRAIN; ACETYLASPARTYLGLUTAMATE; DOPAMINE;
Keywords:
cocaine; glutamate; NAALADase; conditioned place preference;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Ashby, CR St Johns Univ, Coll Pharm & Allied Hlth Profess, PHS Dept, 8000 Utopia Pkwy, Jamaica, NY 11439 USA St Johns Univ 8000 Utopia Pkwy Jamaica NY USA 11439 NY 11439 USA
Citazione:
B.S. Slusher et al., "Expression and acquisition of the conditioned place preference response tococaine in rats is blocked by selective inhibitors of the enzyme N-acetylated-alpha-linked-acidic dipeptidase (NAALADase)", SYNAPSE, 41(1), 2001, pp. 22-28

Abstract

In this study we examined the effect of 2-(phosphonomethyl)pentanedioic acid (2-PMPA) and GPI 5693, selective inhibitors of the enzyme N-Acetylated-alpha -Linked-Acidic Dipeptidase (NAALADase; glutamate carboxypeptidase II; EC no. 3.4.17.21), which cleaves glutamate from the dipeptide N-acetyl-aspartyl-glutamate (NAAG), on the conditioned place preference (CPP) response to cocaine in male rats. The i.p. administration of 15 mg/kg of cocaine produced a significant CPP response. The acquisition and expression of the CPP response to cocaine was blocked by the i.p. administration of 100 mg/kg of 2-PMPA and the p.o. administration of 30 mg/kg of GPI 5693. In contrast, neither 2-PMPA nor GPI 5693 produced a CPP or conditioned place aversion response when administered alone. Furthermore, neither 2-PMPA or GPI 5693 altered the expression of the CPP response to food. These results indicate that NAALADase inhibitors block the incentive motivational value of cocaine, suggesting that such agents may be of use in treating cue-induced craving in cocaine addicts. Synapse 41:22-28, 2001. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 24/01/20 alle ore 12:22:48