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Titolo:
Circulating insulin-like growth factor-I and benign prostatic hyperplasia - A prospective study
Autore:
Stattin, P; Kaaks, R; Riboli, E; Ferrari, P; Dechaud, H; Hallmans, G;
Indirizzi:
Umea Univ Hosp, Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 t Urol & Androl, S-90185 Umea, Sweden Int Agcy Res Canc, F-69372 Lyon, France Int Agcy Res Canc Lyon France F-69372 gcy Res Canc, F-69372 Lyon, France Hop Antiquaille, Cent Lab Biochem, Lyon, France Hop Antiquaille Lyon France Antiquaille, Cent Lab Biochem, Lyon, France Univ Umea Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden Univ Umea Hosp Umea Sweden S-90185 Hlth & Clin Med, S-90185 Umea, Sweden
Titolo Testata:
SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
fascicolo: 2, volume: 35, anno: 2001,
pagine: 122 - 126
SICI:
0036-5599(200104)35:2<122:CIGFAB>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEINS; HEALTHY-SUBJECTS; CANCER RISK; IGF-I; COMMUNITY; HORMONE; MEN; INSULIN-LIKE-GROWTH-FACTOR-1; PREVALENCE; COUNTRIES;
Keywords:
benign prostatic hyperplasia; insulin-like growth factor-I; plasma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Stattin, P Umea Univ Hosp, Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ Hosp Umea Sweden S-90185 drol, S-90185 Umea, Sweden
Citazione:
P. Stattin et al., "Circulating insulin-like growth factor-I and benign prostatic hyperplasia - A prospective study", SC J UROL N, 35(2), 2001, pp. 122-126

Abstract

Objective: The aim of this study was to investigate the role of insulin-like growth factor-I (IGF-I), a strongly mitogenic and anti-apoptotic factor,in the development of benign prostatic hyperplasia (BPH). The bioactivity of IGF-I within tissues depends on circulating levels, as well as on the local production of IGF-I and the presence of IGF-binding proteins (IGFBPs). The IGFBPs regulate the efflux of IGF-I to the extravascular space and the bioavailability of IGF-I within tissues. Material and Methods: Within the Northern Sweden Health and Disease Study,60 cases of BPH defined by a history of prostate resection were identified, and two controls per case were selected. IGF-I, IGFBP-1. IGFBP-3 and insulin were measured by immuno-radiometric assays in stored plasma samples drawn a mean of 3.2, years before surgery. Results: The risk of BPH increased with increasing quartile levels of IGF-I adjusted fbr IGFBP-3 (p(trend) = 0.10) up to a relative risk of 2.16 (95%confidence interval 0.83-5.64) for the highest quartile. The risk decreased with increasing levels of IGFBP-1 (p(trend) = 0.10). Conclusions: Our results suggest that elevated IGF-I bioactivity may stimulate the development of BPH; however, they were not statistically significant and require confirmation from larger studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:09:44