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Titolo:
Cardiac metabolism and function in patients with multiple sclerosis: A combined P-31-MR-spectroscopy and MRI study
Autore:
Beer, M; Sandstede, J; Weilbach, F; Spindler, M; Buchner, S; Krug, A; Kostler, H; Pabst, T; Kenn, W; Landschutz, W; von Kienlin, M; Toyka, KV; Ertl, G; Gold, R; Hahn, D;
Indirizzi:
Univ Wurzburg, Inst Rontgendiagnost, D-97070 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97070 agnost, D-97070 Wurzburg, Germany Univ Wurzburg, Neurol Klin, D-8700 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-8700 rol Klin, D-8700 Wurzburg, Germany Univ Wurzburg, Med Klin, D-8700 Wurzburg, Germany Univ Wurzburg WurzburgGermany D-8700 Med Klin, D-8700 Wurzburg, Germany Univ Wurzburg, Phys Inst 5, Wurzburg, Germany Univ Wurzburg Wurzburg Germany Wurzburg, Phys Inst 5, Wurzburg, Germany
Titolo Testata:
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
fascicolo: 5, volume: 173, anno: 2001,
pagine: 399 - 404
SICI:
1438-9029(200105)173:5<399:CMAFIP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HEART; MYOCARDIUM; ABNORMALITIES; DYSFUNCTION; HYPERTROPHY; PATTERNS; RAT;
Keywords:
MR spectroscopy; MR-imaging; multiple sclerosis; heart disease; heart, functional analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Beer, M Univ Wurzburg, Inst Rontgendiagnost, Josef Schneider Str 2, D-97070 Wurzburg, Germany Univ Wurzburg Josef Schneider Str 2 Wurzburg Germany D-97070 many
Citazione:
M. Beer et al., "Cardiac metabolism and function in patients with multiple sclerosis: A combined P-31-MR-spectroscopy and MRI study", ROFO-F RONT, 173(5), 2001, pp. 399-404

Abstract

Objective: Involvement of the autonomic system in multiple sclerosis (MS) may concur with dysfunction of the cardiovascular system. The introduction of potentially cardiotoxic immunosuppressive drugs like Mitoxantrone into the treatment of MS warrants proper assessment of preexisting heart disease. However, systematic analyses of functional and metabolic derangements in MS are missing. Using quantitative P-31-MR-spectroscopy (MRS) and MR-imaging(MRI) metabolic and functional parameters were analyzed in patients with MS in comparison to healthy volunteers. Subjects/Methods: 14/15 patients with MS could be included in the study, as the MRS examination of one patient had to be excluded from analysis due to movement during the examination. Using chemical shift imaging (CSI) and AMARES, phosphocreatine (PCr) to adenosine triphosphate (ATP) ratios, characterizing myocardial high-energy phosphate metabolism, were determined. Additionally, absolute concentrations of PCr and ATP were calculated by SLOOP (Spatial Localization with Optimal Pointspread Function). Analysis of functional changes was performed by Cine-MRI. 14 healthy volunteers matched for age and gender served as control. Results: A significant decrease of absolute PCr concentration was observed in patients with MS compared to matched volunteers (p <0.05), whereas ATP concentrations showed no significant changes (p=0.27). Metabolite ratios calculated by SLOOP or AMARES showed a tendency to be reduced in patients, however, did not reach significance (p=0.08, SLOOP; p=0.47, AMARES). Using volunteers' mean values +/- 2xSD as cut off value revealed PCr changes in 5 of 14 patients, whereas only 2 also had pathologic PCr/ATP ratios. Functional analysis by MRI depicted depressed left ventricular ejection fraction in 4 patients. Conclusions: The reduction in cardiac high-energy phosphates in somepatients with MS; points to a subclinical involvement of the heart. This may be important for treatment with potentially cardiotoxic drugs. Longitudinal studies are need to understand the clinical relevance of our findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:54:35