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Titolo:
Silencing of CD21 expression in synovial lymphocytes is independent of methylation of the CD21 promoter CpG island
Autore:
Schwab, J; Illges, H;
Indirizzi:
Univ Konstanz, Fac Sci, Dept Biol, D-78457 Constance, Germany Univ Konstanz Constance Germany D-78457 Biol, D-78457 Constance, Germany
Titolo Testata:
RHEUMATOLOGY INTERNATIONAL
fascicolo: 4, volume: 20, anno: 2001,
pagine: 133 - 137
SICI:
0172-8172(200105)20:4<133:SOCEIS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; COMPLEMENT C3 RECEPTORS; T-DEPENDENT ANTIGEN; HUMAN THYMOCYTES; RHEUMATOID-ARTHRITIS; B-LYMPHOCYTES; CELL LINE; CR-2; INFECTION;
Keywords:
CD21; methylation; B lymphocytes; rheumatoid arthritis; reactive arthritis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Illges, H Univ Konstanz, Fac Sci, Dept Biol, M662, D-78457 Constance, Germany Univ Konstanz M662 Constance Germany D-78457 Constance, Germany
Citazione:
J. Schwab e H. Illges, "Silencing of CD21 expression in synovial lymphocytes is independent of methylation of the CD21 promoter CpG island", RHEUM INTL, 20(4), 2001, pp. 133-137

Abstract

The complement receptor II (CD21) recognises the complement component C3d of immune complexes. Expression of the CD21 gene is tightly regulated during B lymphocyte differentiation. Only mature B lymphocytes express CD21 but not pro-, pre-, or plasma B lymphocytes. Previously we found that pro-, pre-, and intermediate B lymphocytes contain a methylated CpG island and do not express CD21. CD21-expressing mature B lymphocytes, plasma B lymphocytes,and nonlymphoid cells carried a demethylated CD21 CpG island. Furthermore,we found that synovial lymphocytes from patients with rheumatic disease show reduced expression of CD21. This observation tempted us to analyse the methylation status of the CD21 CpG island in peripheral blood mononuclear cells and synovial fluid mononuclear cells derived from these patients. Whilemethylation is involved in silencing CD21 in early types of B lymphocytes,we found the CD21-CpG island to be demethylated in peripheral blood mononuclear cells and synovial fluid mononuclear cells of patient DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 02:14:32