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Titolo:
Chronic tobacco smoke exposure increases cough to capsaicin in awake guinea pigs
Autore:
Bergren, DR;
Indirizzi:
Creighton Univ, Sch Med, Dept Biomed Sci, Div Physiol, Omaha, NE 68178 USACreighton Univ Omaha NE USA 68178 d Sci, Div Physiol, Omaha, NE 68178 USA
Titolo Testata:
RESPIRATION PHYSIOLOGY
fascicolo: 2, volume: 126, anno: 2001,
pagine: 127 - 140
SICI:
0034-5687(200106)126:2<127:CTSEIC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIGARETTE-SMOKE; SUBSTANCE-P; NEUTRAL ENDOPEPTIDASE; BRONCHIAL-ASTHMA; CITRIC-ACID; HYPERRESPONSIVENESS; AFFERENT; REFLEX; DOGS; STIMULATION;
Keywords:
afferents; pulmonary; C-fibers; disease; cough; asthma; irritants; tobacco smoke; mammals; guinea pig; mediators; bradykinin; histamine; pharmacological agents; capsaicin; methacholine; resistance; airways;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Bergren, DR Creighton Univ, Sch Med, Dept Biomed Sci, Div Physiol, 2500 Calif Plaza, Omaha, NE 68178 USA Creighton Univ 2500 Calif Plaza Omaha NE USA68178 E 68178 USA
Citazione:
D.R. Bergren, "Chronic tobacco smoke exposure increases cough to capsaicin in awake guinea pigs", RESP PHYSL, 126(2), 2001, pp. 127-140

Abstract

Chronic exposure to irritants such as tobacco smoke (TS) can induce spontaneous and enhanced irritant-induced coughing, especially in asthma. To determine if the mechanism of enhanced coughing involves activation of capsaicin-sensitive sensory receptors (C-fibers), we exposed both non-sensitized (NS) and ovalbumin-sensitized guinea pigs to TS (5 mg/L air, 30 min exposure,and 7 days/week). Similar groups were exposed to compressed air. After 90 days of exposure, we challenged the airways with capsaicin, bradykinin, histamine and methacholine. Capsaicin induced coughing as well as bronchoconstriction in guinea pigs exposed to TS. In ovalbumin (OA) guinea pigs coughing and bronchoconstriction were enhanced. Tachykinin receptor antagonists attenuated coughing to both capsaicin and acute TS challenge. Bradykinin alsoinduced coughing and bronchoconstriction in guinea pigs exposed to TS. There was no statistical separation between the two TS groups however. Histamine and methacholine induced similar bronchoconstriction but fewer coughs inall four experimental groups. In conclusion, chronic TS exposure induced coughing to capsaicin and bradykinin challenge. The effect of capsaicin was further enhanced in OA guinea pigs. Enhanced coughing induced by TS exposure likely involves activation of capsaicin-sensitive sensory C-fibers and neuropeptide release with possible subsequent activation of rapidly-adapting receptors. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:32:58