Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Secondary laboratory recurrence after radical prostatectomy: multivariate analysis of clinical, laboratory and histological prognostic factors.
Autore:
Malavaud, B; Game, X; Villers, A; Mouzin, M; Mazerolles, C; Rischmann, P; Sarramon, JP;
Indirizzi:
CHU Rangueil, Serv Chirurg Urol & Transplantat Renale, F-31400 Toulouse, France CHU Rangueil Toulouse France F-31400 at Renale, F-31400 Toulouse, France Hop Purpan, Serv Anatomopathol, Toulouse, France Hop Purpan Toulouse France Purpan, Serv Anatomopathol, Toulouse, France
Titolo Testata:
PROGRES EN UROLOGIE
fascicolo: 2, volume: 11, anno: 2001,
pagine: 277 - 282
SICI:
1166-7087(200104)11:2<277:SLRARP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
FRE
Soggetto:
RETROPUBIC PROSTATECTOMY; TUMOR VOLUME; CANCER; PROGRESSION; ANTIGEN; MEN; PSA; ADENOCARCINOMA; SPECIMENS; CARCINOMA;
Keywords:
prostate; cancer; radical prostatectomy; prognostic factors; recurrence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Game, X CHU Rangueil, Serv Chirurg Urol & Transplantat Renale, F-31400 Toulouse, France CHU Rangueil Toulouse France F-31400 e, F-31400 Toulouse, France
Citazione:
B. Malavaud et al., "Secondary laboratory recurrence after radical prostatectomy: multivariate analysis of clinical, laboratory and histological prognostic factors.", PROG UROL, 11(2), 2001, pp. 277-282

Abstract

Objectives: To defined the clinical, laboratory and histological variablesassociated with secondary elevation, after an undetectable phase, of PSA after radical prostatectomy. Materials and Methods: this was a prospective study of 83 consecutive patients undergoing retropubic radical prostatectomy with an undetectable postoperative criteria (age, total PSA, Gleason score on biopsies, positive apical biopsies, clinical stage) and four postoperative criteria specimen, positive margins, follow-up) for secondary laboratory progression was studied by univariate and multivariate analysis. Results: With a median follow-up of 36 months, the laboratory recurrence rate was 19%. Laboratory recurrence was associated with a biopsy Gleason score greater than or equal to 7 (p=0.04), a high pathological stage (p=0.03),a high histological score (Gleason greater than or equal to 7) (p <0.01) and positive margins (p=0.04). Logistic regression identified a Gleason score on the operative specimen greater than or equal to 7 to be the only element predictive of secondary laboratory progression. Conclusion: The concept of positive margins or high pathological stage is insufficient to identify the risk of laboratory progression after radical prostatectomy. The Gleason score, which evaluates tumour aggressiveness, therisk of micrometastases or periprostatic extention, therefore appears to be more useful.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:50:43