Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Very high mutation rate in offspring of Chernobyl accident liquidators
Autore:
Weinberg, HS; Korol, AB; Kirzhner, VM; Avivi, A; Fahima, T; Nevo, E; Shapiro, S; Rennert, G; Piatak, O; Stepanova, EI; Skvarskaja, E;
Indirizzi:
Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel Univ Haifa Haifa Israel IL-31905 fa, Inst Evolut, IL-31905 Haifa, Israel Carmel Med Ctr, Natl Kupat Holim Canc Control Ctr, IL-34362 Haifa, Israel Carmel Med Ctr Haifa Israel IL-34362 Control Ctr, IL-34362 Haifa, Israel Technion Israel Inst Technol, Fac Med, IL-34362 Haifa, Israel Technion Israel Inst Technol Haifa Israel IL-34362 L-34362 Haifa, Israel Ukraine Acad Med Sci, Res Ctr Radiat Med, UA-254050 Kiev, Ukraine Ukraine Acad Med Sci Kiev Ukraine UA-254050 Med, UA-254050 Kiev, Ukraine
Titolo Testata:
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
fascicolo: 1471, volume: 268, anno: 2001,
pagine: 1001 - 1005
SICI:
0962-8452(20010522)268:1471<1001:VHMRIO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATOMIC-BOMB RADIATION; GERM-CELLS; GENETIC INSTABILITY; DNA; MICE; HUMANS; POLYMERASE; EXPOSURE; DISASTER; GENOME;
Keywords:
germline mutation; Chernobyl; liquidators; DNA fingerprinting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Nevo, E Univ Haifa, Inst Evolut, IL-31905 Haifa, Israel Univ Haifa HaifaIsrael IL-31905 Evolut, IL-31905 Haifa, Israel
Citazione:
H.S. Weinberg et al., "Very high mutation rate in offspring of Chernobyl accident liquidators", P ROY SOC B, 268(1471), 2001, pp. 1001-1005

Abstract

Exposure to ionizing radiation has long been suspected to increase mutation load in humans. Nevertheless, such events as atomic bombing seem not to have yielded significant genetic defects. The Chernobyl accident created a different, long-term exposure to radiation. Clean-up teams (or 'liquidators') of the Chernobyl reactor are among those who received the highest doses, presumably in some combination of acute and chronic forms. In this study, children born to liquidator families (currently either in the Ukraine or Israel) conceived after (CA) parental exposure to radiation were screened for the appearance of new fragments using multi-site DNA fingerprinting. Their sibs conceived before (CB) exposure served as critical internal controls, in addition to external controls (non-exposed families). An unexpectedly high (sevenfold) increase in the number of new bands in CA individuals compared with the level seen in controls was recorded. A strong tendency for the number of new bands to decrease with elapsed time between exposure and offspring conception was established for the Ukrainian families. These results indicate that low doses of radiation can induce multiple changes in human germline DNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:11:35