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Titolo:
Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
Autore:
Tansey, JT; Sztalryd, C; Gruia-Gray, J; Roush, DL; Zee, JV; Gavrilova, O; Reitman, ML; Deng, CX; Li, C; Kimmel, AR; Londos, C;
Indirizzi:
NIDDKD, Cellular & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 & Dev Biol Lab, NIH, Bethesda, MD 20892 USA NIDDKD, Diabet Branch, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA20892 , Diabet Branch, NIH, Bethesda, MD 20892 USA NIDDKD, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MD USA 20892 ev & Dis Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 11, volume: 98, anno: 2001,
pagine: 6494 - 6499
SICI:
0027-8424(20010522)98:11<6494:PARIAL>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-SENSITIVE LIPASE; DEPENDENT PROTEIN-KINASE; LIPID STORAGE DROPLET; INSULIN-RESISTANCE; DIABETES-MELLITUS; RAT ADIPOCYTES; MICE; LIPODYSTROPHY; MECHANISMS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Londos, C NIDDKD, Cellular & Dev Biol Lab, NIH, Bldg 6,Room B1-32, Bethesda, MD 20892 USA NIDDKD Bldg 6,Room B1-32 Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
J.T. Tansey et al., "Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity", P NAS US, 98(11), 2001, pp. 6494-6499

Abstract

Perilipin coats the lipid droplets of adipocytes and is thought to have a role in regulating triacylglycerol hydrolysis. To study the role of perilipin in vivo, we have created a perilipin knockout mouse. Perilipin null (peri(-/-)) and wild-type (peri(+/+)) mice consume equal amounts of food, but the adipose tissue mass in the null animals is reduced to approximate to 30%of that in wild-type animals. Isolated adipocytes of perilipin null mice exhibit elevated basal lipolysis because of the loss of the protective function of perilipin. They also exhibit dramatically attenuated stimulated lipolytic activity, indicating that perilipin is required for maximal lipolyticactivity. Plasma leptin concentrations in null animals were greater than expected for the reduced adipose mass. The peri(-/-) animals have a greater lean body mass and increased metabolic rate but they also show an increasedtendency to develop glucose intolerance and peripheral insulin resistance. When fed a high-fat diet, the perilipin null animals are resistant to diet-induced obesity but not to glucose intolerance. The data reveal a major role for perilipin in adipose lipid metabolism and suggest perilipin as a potential target for attacking problems associated with obesity.

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Documento generato il 16/07/20 alle ore 18:50:21