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Titolo:
Overexpression of p27(Kip1) lengthens the G(1) phase in a mouse model thattargets inducible gene expression to central nervous system progenitor cells
Autore:
Mitsuhashi, T; Aoki, Y; Eksioglu, YZ; Takahashi, T; Bhide, PG; Reeves, SA; Caviness, VS;
Indirizzi:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Dev Neurobiol, Charlestown, MA 02129 USA Harvard Univ Charlestown MA USA 02129 eurobiol, Charlestown, MA 02129 USA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cent Nervous Syst SignalingLab,Ctr Aging Genet &, Charlestown, MA 02129 USA Harvard Univ Charlestown MA USA 02129 Genet &, Charlestown, MA 02129 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 11, volume: 98, anno: 2001,
pagine: 6435 - 6440
SICI:
0027-8424(20010522)98:11<6435:OOPLTG>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
G1 PHASE; PROLIFERATIVE EPITHELIUM; CEREBRAL-CORTEX; MICE LACKING; CYCLE; PROGRESSION; SPECIFICATION; HYPERPLASIA; GROWTH; ARREST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Reeves, SA Harvard Univ, Sch Med, Massachusetts Gen Hosp, Cent Nervous Syst SignalingLab,Ctr Aging Genet &, Charlestown, MA 02129 USA Harvard Univ Charlestown MA USA 02129 harlestown, MA 02129 USA
Citazione:
T. Mitsuhashi et al., "Overexpression of p27(Kip1) lengthens the G(1) phase in a mouse model thattargets inducible gene expression to central nervous system progenitor cells", P NAS US, 98(11), 2001, pp. 6435-6440

Abstract

We describe a mouse model in which p27(Kip1) transgene expression is spatially restricted to the central nervous system neuroepithelium and temporally controlled with doxycycline. Transgenespecific transcripts are detectablewithin 6 h of doxycycline administration, and maximum nonlethal expressionis approached within 12 h, After 18-26 h of transgene expression, the G(1)phase of the cell cycle is estimated to increase from 9 to 13 h in the neocortical neuroepithelium, the maximum G(1) phase length attainable in this proliferative population in normal mice. Thus our data establish a direct link between p27(Kip1) and control of G(1) phase length in the mammalian central nervous system and unveil intrinsic mechanisms that constrain the G(1)phase length to a putative physiological maximum despite ongoing p27(Kip1)transgene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:16:16