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Titolo:
A novel method for the prediction of functional biological activity of polyethylene wear debris
Autore:
Fisher, J; Bell, J; Barbour, PSM; Tipper, JL; Matthews, JB; Besong, AA; Stone, MH; Ingham, E;
Indirizzi:
Univ Leeds, Sch Mech Engn, Leeds LS2 9JT, W Yorkshire, England Univ LeedsLeeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England Gen Infirm, Dept Orthopaed Surg, Leeds LS1 3EX, W Yorkshire, England Gen Infirm Leeds W Yorkshire England LS1 3EX S1 3EX, W Yorkshire, England
Titolo Testata:
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
fascicolo: H2, volume: 215, anno: 2001,
pagine: 127 - 132
SICI:
0954-4119(2001)215:H2<127:ANMFTP>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL JOINT REPLACEMENT; IN-VITRO; PROSTHESES; PARTICLES; SIZE;
Keywords:
joint replacement; polyethylene; wear debris; functional biological activity; model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Engineering, Computing & Technology
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Fisher, J Univ Leeds, Sch Mech Engn, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT Yorkshire, England
Citazione:
J. Fisher et al., "A novel method for the prediction of functional biological activity of polyethylene wear debris", P I MEC E H, 215(H2), 2001, pp. 127-132

Abstract

The comparative performance of artificial hip joints has been extensively investigated in vitro through measurements of wear volumes. In vivo a majorcause of long-term failure is wear-debris-induced osteolysis. These adverse biological reactions are not simply dependent on wear volume, but are also controlled by the size and volumetric concentration of the debris. A novel model is presented which predicts functional biological activity; this isdetermined by integrating the product of the biological activity function and the volumetric concentration function with the wear volume over the whole particle size range. This model combines conventional wear volume measurements with particle analysis and the output from ill vitro, cell culture studies to provide a new indicator of osteolytic potential. The application of the model is demonstrated through comparison of the functional biological activity of wear debris from polyethylene acetabular cups articulating under three different conditions in a hip joint simulator.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:14:49