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Titolo:
Excitotoxicity of Lathyrus sativus neurotoxin in leech retzius neurons
Autore:
Cemerikic, D; Nedeljkov, V; Lopicic, S; Dragovic, S; Beleslin, B;
Indirizzi:
Fac Med Belgrade, Dept Pathol Physiol, YU-11000 Belgrade, Yugoslavia Fac Med Belgrade Belgrade Yugoslavia YU-11000 11000 Belgrade, Yugoslavia
Titolo Testata:
PHYSIOLOGICAL RESEARCH
fascicolo: 2, volume: 50, anno: 2001,
pagine: 205 - 214
SICI:
0862-8408(2001)50:2<205:EOLSNI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; GLUTAMATE RECEPTORS; GLIAL-CELLS; EXCITATION; CHANNELS; KAINATE; MUSCLE; ACID;
Keywords:
input membrane resistance; intracellular Ca2+ concentration; intracellular Na+ and K+ activities; Lathyrus sativus excitotoxicity; leech Retzius neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Cemerikic, D Fac Med Belgrade, Dept Pathol Physiol, Dr Subot 1-11, YU-11000 Belgrade, Yugoslavia Fac Med Belgrade Dr Subot 1-11 Belgrade Yugoslavia YU-11000
Citazione:
D. Cemerikic et al., "Excitotoxicity of Lathyrus sativus neurotoxin in leech retzius neurons", PHYSL RES, 50(2), 2001, pp. 205-214

Abstract

The effects of Lathyrus sativus neurotoxin were studied on the cell membrane potential and cellular cation composition in Retzius nerve cells of the leech Haemopis sanguisuga, with ion-selective microelectrodes using liquid ion-exchangers. Bath application of 10(-4) mol/l Lathyrus sativus neurotoxin for 3 min depolarized the cell membrane potential and decreased the inputresistance of directly polarized membrane in Retzius neurons. At the same time the cellular Na+ activity increased and cellular K+ activity decreasedwith slow but complete recovery, while the intracellular Ca2+ concentration was not changed, Na+-free Ringer solutions inhibited the depolarizing effect of the neurotoxin on the cell membrane potential. Zero-Ca2+ Ringer solution or Ni2+-Ringer solution had no influence on the depolarizing effect ofthe neurotoxin on the cell membrane potential. It is obvious that the increase in membrane conductance and depolarization of the cell membrane potential are due to an influx of Na+ into the cell accompanied by an efflux of K from the cell.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:11:11