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Titolo:
An ideal biological marker of Alzheimer's disease: Dream or reality?
Autore:
Ripova, D; Strunecka, A;
Indirizzi:
Charles Univ, Prague Psychiat Ctr, Biochem Lab, Prague 18103 8, Czech Republic Charles Univ Prague Czech Republic 18103 8 rague 18103 8, Czech Republic Charles Univ, Fac Sci, Dept Physiol & Dev Biol, Prague 18103 8, Czech Republic Charles Univ Prague Czech Republic 18103 8 rague 18103 8, Czech Republic
Titolo Testata:
PHYSIOLOGICAL RESEARCH
fascicolo: 2, volume: 50, anno: 2001,
pagine: 119 - 129
SICI:
0862-8408(2001)50:2<119:AIBMOA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; CEREBROSPINAL-FLUID TAU; POSITRON EMISSION TOMOGRAPHY; MILD COGNITIVE IMPAIRMENT; BIOCHEMICAL MARKER; DIAGNOSTIC MARKER; APOLIPOPROTEIN-E; GENE; PATHOLOGY; BETA-AMYLOID((1-42));
Keywords:
Alzheimer's disease; biological peripheral marker; beta-amyloid; protein tau; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Ripova, D Charles Univ, Prague Psychiat Ctr, Biochem Lab, Ustavni 91, Prague 18103 8, Czech Republic Charles Univ Ustavni 91 Prague Czech Republic 18103 8 Republic
Citazione:
D. Ripova e A. Strunecka, "An ideal biological marker of Alzheimer's disease: Dream or reality?", PHYSL RES, 50(2), 2001, pp. 119-129

Abstract

Senile dementia of Alzheimer's type (AD) is commonly characterized as a neurodegenerative disorder, which exhibits gradual changes of consciousness, loss of memory, perception and orientation as well as loss of personality and intellect. AD prevalence increases dramatically with age and is the fourth cause of death in Europe and in the USA. Currently, there are no available biological markers, which gives clinicians no other alternative than to rely upon clinical diagnosis by exclusion. There is no assay of objective ante mortem biochemical phenomena that relate to the pathophysiology of thisdisease. The pathophysiology of AD is connected with alterations in neurotransmission, plaque formation, cytoskeletal abnormalities and disturbances of calcium homeostasis. The search for a test, which is noninvasive, simple, cheap and user-friendly, should be directed at accessible body fluids. Only abnormalities replicated in large series across different laboratories fulfilling the criteria for a biological marker are likely to be of relevance in diagnosing AD. To date, only the combination of cerebrospinal fluid tau and A beta 42 most closely approximate an ideal biomarker of Alzheimer's disease. A short review on the role of biological markers in AD on the basis of the literature, contemporary knowledge and our own recent findings arepresented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:30:05