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Titolo:
Are ejection fractions from gated SPECT perfusion studies clinically useful? A comparison with radionuclide ventriculography
Autore:
Wright, GA; McDade, M; Keeble, W; Martin, W; Hutton, I;
Indirizzi:
Glasgow Royal Infirm, Dept Med Cardiol, Glasgow, Lanark, Scotland Glasgow Royal Infirm Glasgow Lanark Scotland , Glasgow, Lanark, Scotland Hull Hosp, Dept Nucl Med, Hull, N Humberside, England Hull Hosp Hull N Humberside England ucl Med, Hull, N Humberside, England
Titolo Testata:
PHYSIOLOGICAL MEASUREMENT
fascicolo: 2, volume: 22, anno: 2001,
pagine: 413 - 422
SICI:
0967-3334(200105)22:2<413:AEFFGS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; ANGIOGRAPHY; VOLUMES; TL-201;
Keywords:
gated myocardial perfusion SPECT; ejection fraction; technetium-99m agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Wright, GA Princess Royal Hosp, Dept Nucl Med, Saltshouse Rd, Hull HU8 9HE, N Humberside, England Princess Royal Hosp Saltshouse Rd Hull N HumbersideEngland HU8 9HE
Citazione:
G.A. Wright et al., "Are ejection fractions from gated SPECT perfusion studies clinically useful? A comparison with radionuclide ventriculography", PHYSL MEAS, 22(2), 2001, pp. 413-422

Abstract

Gated SPECT (GSPECT) was evaluated fur the measurement of left ventricularejection fraction (LVEF) by comparing with equilibrium Sated radionuclide ventriculography (RNVG). A total of 99 subjects: underwent GSPECT and RNVG imaging. All studies were acquired in list mode with GSPECT studies processed to give 16- and 8-frames per R-R interval, and RNVG studies 24 Frames per R-R interval. The Cedars-Sinai QGS software was used to calculate ejection fraction fi om GSPECT studies. RNVG studies were processed using a manually drawn single legion of interest technique. Comparison of LVEF from GSPECT with RNVG yielded correlation coefficients of 0.82 and 0.81 for 16- and 8-frame GSPECT studies respectively. The mean 95% prediction interval was 33+/- 11 percentage points for both 16- and 8-frame studies, indicating a great disparity between predicted ejection fraction values from GSPECT and actual RNVG values. Subgroup analysis of 29 patients with pathological Q-waveevidence of myocardial infarction demonstrated a poorer correlation coefficient of r = 0.69. Subgroup analysis of 32 patients with end-diastolic volumes < 100 mi demonstrated a poorer correlation coefficient of r = 0.32. Ejection fl actions calculated from 16- and 8-frame studies showed a correlation of 0.99 with a mean 95% prediction interval of 8.7 +/-0.04 percentage points. The 8-frame studies underestimated LVEF by 3.6 +/- 2.3% compared to the 16-frame studies. In conclusion, left ventricular ejection fractions calculated using the QGS algorithm from GSPECT studies are inadequate for use in clinical practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 23:19:23