Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CONVERSION OF ARACHIDONIC-ACID TO TETRADECADIENOIC ACID BY PEROXISOMAL OXIDATION
Autore:
SPECTOR AA; WILLIARD DE; KADUCE TL; GORDON JA;
Indirizzi:
UNIV IOWA,DEPT BIOCHEM,4-403 BSB IOWA CITY IA 52242
Titolo Testata:
Prostaglandins, leukotrienes and essential fatty acids
fascicolo: 1, volume: 57, anno: 1997,
pagine: 101 - 105
SICI:
0952-3278(1997)57:1<101:COATTA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SKIN FIBROBLASTS; ENDOTHELIAL-CELLS; BETA-OXIDATION; RETROCONVERSION; METABOLITE; TRANSDUCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Spector et al., "CONVERSION OF ARACHIDONIC-ACID TO TETRADECADIENOIC ACID BY PEROXISOMAL OXIDATION", Prostaglandins, leukotrienes and essential fatty acids, 57(1), 1997, pp. 101-105

Abstract

Human skin fibroblasts convert [5,6,8,9,11,12,14,15-H-3]arachidonic acid to two radiolabeled polar metabolites that accumulate in the culture medium. Previous studies identified the most abundant of these products as 4,7,10-hexadecatrienoic acid (16:3). We have now identified the second metabolite as 5,8-tetradecadienoic acid (14:2). Fibroblasts deficient in mitochondrial long-chain acyl coenzyme A dehydrogenase produce increased amounts of 14:2 from arachidonic acid. By contrast, Zellweger fibroblasts which are deficient in peroxisomal beta-oxidation do not convert arachidonic acid to either 14.2 or 16:3. These results demonstrate that 14:2 can be synthesized from arachidonic acid, that this oxidative process occurs in the peroxisomes, and that the pathway does not function in Zellweger's syndrome and similar diseases where there is a genetic deficiency in peroxisomal beta-oxidation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:39:36