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Titolo:
Identification of hypoxia-responsive genes in a dopaminergic cell line by subtractive cDNA libraries and microarray analysis
Autore:
Beitner-Johnson, D; Seta, K; Yuan, Y; Kim, HW; Rust, RT; Conrad, PW; Kobayashi, S; Millhorn, DE;
Indirizzi:
Univ Cincinnati, Dept Cellular & Mol Physiol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Physiol, Cincinnati, OH 45267 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 273 - 281
SICI:
1353-8020(200107)7:3<273:IOHGIA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE-HYDROXYLASE GENE; RAT PC12 CELLS; INDUCIBLE FACTOR-1; TRANSCRIPTIONAL REGULATION; PARKINSONS-DISEASE; CAROTID-BODY; K+ CURRENT; EXPRESSION; PROTEIN; BINDING;
Keywords:
oxygen/pheochromocytoma; genomics; tyrosine hydroxylase; carotid body; type I cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Millhorn, DE Univ Cincinnati, Dept Cellular & Mol Physiol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 innati, OH 45267 USA
Citazione:
D. Beitner-Johnson et al., "Identification of hypoxia-responsive genes in a dopaminergic cell line by subtractive cDNA libraries and microarray analysis", PARKINS R D, 7(3), 2001, pp. 273-281

Abstract

Transplantation of dopamine-secreting cells harvested from fetal mesencephalon directly into the striatum has had limited success as a therapy for Parkinson's disease. A major problem is that the majority of the cells die during the first 3 weeks following transplantation. Hypoxia in the tissue surrounding the graft is a potential cause of the cell death. We have used subtractive cDNA libraries and microarray analysis to identify the gene expression profile that regulates tolerance to hypoxia. An improved understandingof the molecular basis of hypoxia-tolerance may allow investigators to engineer cells that can survive in the hypoxic environment of the brain parenchyma following transplantation. (C) 2001 Published by Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:17:31