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Titolo:
Endocytosis and downregulation of G protein-coupled receptors
Autore:
von Zastrow, M;
Indirizzi:
Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Calif San Francisco, Cell Biol Program, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 265 - 271
SICI:
1353-8020(200107)7:3<265:EADOGP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MU-OPIOID RECEPTOR; BETA-ADRENERGIC RECEPTORS; CLATHRIN-MEDIATED ENDOCYTOSIS; EXCHANGER REGULATORY FACTOR; BETA(2)-ADRENERGIC RECEPTOR; BETA-2-ADRENERGIC RECEPTOR; DOWN-REGULATION; PLASMA-MEMBRANE; ALPHA(2)-ADRENERGIC RECEPTORS; INTRACELLULAR TRAFFICKING;
Keywords:
receptor; G protein; endocytosis; receptor regulation; down-regulation; desenitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: von Zastrow, M Box 0984F,LPPI Room LP-A104,401 Parnassus Ave, San Francisco, CA 94143 USA Box 0984F,LPPI Room LP-A104,401 Parnassus Ave San Francisco CA USA 94143
Citazione:
M. von Zastrow, "Endocytosis and downregulation of G protein-coupled receptors", PARKINS R D, 7(3), 2001, pp. 265-271

Abstract

The number of G protein-coupled receptors (GPCRs) displayed at the cell surface is a critical determinant of physiological responsiveness to native ligands and drugs. Downregulation of the number of adrenergic and dopaminergic receptors present on specific neurons can be induced by receptor agonists or by drugs that increase extracellular concentrations of catecholamines such as dopamine. Thus agonist-induced downregulation of GPCRs is of potentially great importance to the treatment of Parkinson's Disease. However, little is known about: biochemical mechanisms that mediate GPCR downregulation. Recent studies of cloned GPCRs have provided exciting insights into specific mechanisms that control endocytosis of receptors from the plasma membrane and regulate proteolytic degradation of receptors. In this review we briefly survey representative studies establishing that multiple mechanisms of GPCR membrane trafficking can function in downregulation function both inneural and non-neural cell types. Then we focus on our present view of mechanisms mediating regulated proteolysis of GPCRs, highlighting recent progress in understanding membrane trafficking of GPCRs from the cell surface tolysosomes. Finally we discuss emerging evidence regarding a specific mechanism that modulates sorting of certain GPCRs between recycling and degradative pathways. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:57:09