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Titolo:
Glutamate is a cotransmitter in ventral midbrain dopamine neurons
Autore:
Rayport, S;
Indirizzi:
NYSPI, Dept Neurosci, New York, NY 10032 USA NYSPI New York NY USA 10032NYSPI, Dept Neurosci, New York, NY 10032 USA Columbia Univ, Dept Psychiat, New York, NY 10032 USA Columbia Univ New York NY USA 10032 Dept Psychiat, New York, NY 10032 USA Columbia Univ, Dept Anat & Cell Biol, New York, NY 10032 USA Columbia Univ New York NY USA 10032 t & Cell Biol, New York, NY 10032 USA Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 261 - 264
SICI:
1353-8020(200107)7:3<261:GIACIV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS NEURONS; LONG-TERM POTENTIATION; STRIATUM IN-VIVO; RAT-BRAIN; RECEPTOR ACTIVATION; SUBSTANTIA-NIGRA; TEGMENTAL AREA; POSTNATAL RAT; SYNAPSES; VITRO;
Keywords:
synaptic heterogeneity; corelease; cell culture; glutamic acid; immunocytochemistry; excitotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Rayport, S NYSPI, Dept Neurosci, 1051 Riverside Dr,Unit 62, New York, NY 10032 USA NYSPI 1051 Riverside Dr,Unit 62 New York NY USA 10032 10032 USA
Citazione:
S. Rayport, "Glutamate is a cotransmitter in ventral midbrain dopamine neurons", PARKINS R D, 7(3), 2001, pp. 261-264

Abstract

Interactions between apparently separate dopaminergic and glutamatergic pathways figure prominently in the pathophysiology of Parkinson's Disease. Soit is surprising that the ventral midbrain dopamine neurons, which give rise to the dopaminergic pathway, may themselves also be glutamatergic. We have addressed this idea in both rat and monkey brain and found that most ventral midbrain dopamine neurons exhibit glutamate immunoreactivity. We used postnatal cell culture to examine ventral midbrain dopamine neurons more closely. In vitro most dopamine neurons exhibit glutamate immunoreactivity, as well as immunoreactivity for phosphate-activated glutaminase, the enzyme principally responsible for the synthesis of neurotransmitter glutamate; inhibition of glutaminase reduces glutamate staining. In single cell microcultures, dopamine neurons make both dopaminergic and glutamatergic synaptic varicosities. Stimulation of individual dopamine neurons evokes a fast excitatory synaptic response mediated by glutamate; it also evokes dopamine release that inhibits the excitatory response via presynaptic D2 receptors. Thus, dopamine neurons appear to exert rapid synaptic actions via their glutamatergic synapses and slower modulatory actions via their dopaminergic synapses, including possibly inhibition of their own glutamatergic synapses. So,in the setting of dopamine neuron demise, there will be a loss of both dopaminergic and glutamatergic inputs to the striatum; furthermore, glutamate released by dopamine neurons may contribute to an excitotoxic cascade and the death of neighboring dopamine neurons. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:27:25