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Titolo:
Multiple system atrophy: new developments in pathophysiology and therapy
Autore:
Robertson, D; Shannon, JR; Jordan, J; Davis, TL; Diedrich, A; Jacob, G; Garland, E; Tellioglu, T; Biaggioni, I;
Indirizzi:
Vanderbilt Univ, NPF Nathan Blaser Shy Drager Res Program, Auton Dysfunct Ctr, Dept Med, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Dept Med, Nashville, TN 37232 USA Vanderbilt Univ, NPF Nathan Blaser Shy Drager Res Program, Auton Dysfunct Ctr, Dept Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Pharmacol, Nashville, TN 37232 USA Vanderbilt Univ, NPF Nathan Blaser Shy Drager Res Program, Auton Dysfunct Ctr, Dept Neurol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA37232 pt Neurol, Nashville, TN 37232 USA Vanderbilt Univ, NPF Nathan Blaser Shy Drager Res Program, Auton Dysfunct Ctr, Dept Psychiat, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Psychiat, Nashville, TN 37232 USA Franz Vollhard Inst, Clin Res Ctr, Berlin, Germany Franz Vollhard Inst Berlin Germany Inst, Clin Res Ctr, Berlin, Germany Rambam Med Ctr, Recanati Auton Dysfunct Ctr, Haifa, Israel Rambam Med CtrHaifa Israel Recanati Auton Dysfunct Ctr, Haifa, Israel
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 257 - 260
SICI:
1353-8020(200107)7:3<257:MSANDI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURE AUTONOMIC FAILURE; CONSENSUS STATEMENT; HYPERTENSION; DEFINITION;
Keywords:
autonomic; multiple system atrophy; hypotension; Shy-Drager syndrome; water; nicotinic antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, D Vanderbilt Univ, NPF Nathan Blaser Shy Drager Res Program, Auton Dysfunct Ctr, Dept Med, 221 Kirkland Hall, Nashville, TN 37232 USA Vanderbilt Univ 221 Kirkland Hall Nashville TN USA 37232 USA
Citazione:
D. Robertson et al., "Multiple system atrophy: new developments in pathophysiology and therapy", PARKINS R D, 7(3), 2001, pp. 257-260

Abstract

There have been substantial advances in the last Ave years in understanding the basic and clinical pathophysiology underlying multiple system atrophy(MSA). Identification of glial cytoplasmic inclusions has been the most important organizing principle for further elucidation of underlying mechanisms. Recently, several unexpected developments at the clinical level have been reported. In this article, we will focus on two of these: (1) the recognition that substantial autonomic function is retained in MSA but not modulated appropriately, and (2) a potent presser effect from ingestion of water,which cannot be explained by currently understood physiologic and pathophysiologic mechanisms. In some patients, water has elicited a 50% increase inblood pressure and been more therapeutically effective than any available presser drug. By careful coordination of the presser effect of water and the depressor effect of carbohydrate-rich food, many patients with MSA can now have their blood pressure controlled without pharmacological intervention. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 10:36:05