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Titolo:
Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease
Autore:
Ferre, S; Popoli, P; Gimenez-Llort, L; Rimondini, R; Muller, CE; Stromberg, I; Ogren, O; Fuxe, K;
Indirizzi:
Natl Inst Drug Abuse, IRP, NIH, Baltimore, MD 21224 USA Natl Inst Drug Abuse Baltimore MD USA 21224 NIH, Baltimore, MD 21224 USA Ist Super Sanita, Dept Pharmacol, I-00161 Rome, Italy Ist Super Sanita Rome Italy I-00161 Dept Pharmacol, I-00161 Rome, Italy Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden Univ Wurzburg, Dept Pharmaceut Chem, Inst Pharm & Food Chem, D-97074 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97074 d Chem, D-97074 Wurzburg, Germany
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 235 - 241
SICI:
1353-8020(200107)7:3<235:AIIFTT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINE D-2 RECEPTORS; C-FOS EXPRESSION; COTRANSFECTED FIBROBLAST CELLS; INDUCED ROTATIONAL BEHAVIOR; A(2A) RECEPTOR; RAT STRIATUM; 6-HYDROXYDOPAMINE-LESIONED RATS; TURNING BEHAVIOR; A(1) RECEPTOR; MESSENGER-RNA;
Keywords:
adenosine receptors; dopamine receptors; receptor/receptor interaction; Parkinson's disease; sensitization; tolerance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Ferre, S Natl Inst Drug Abuse, IRP, NIH, Baltimore, MD 21224 USA Natl InstDrug Abuse Baltimore MD USA 21224 timore, MD 21224 USA
Citazione:
S. Ferre et al., "Adenosine/dopamine interaction: implications for the treatment of Parkinson's disease", PARKINS R D, 7(3), 2001, pp. 235-241

Abstract

Evidence for a role of dopaminergic neurotransmission in the motor effectsof adenosine antagonists, such as caffeine, is reviewed, based on the existence of specific antagonistic interactions between specific subtypes of adenosine and dopamine receptors in the striatum. Both adenosine A(1) and adenosine A(2A) receptor antagonists induce motor activation in rodents. At least a certain degree of dopaminergic activity is required to obtain adenosine antagonist-induced motor activation, with adenosine A(1) antagonists being the most sensitive and non-selective adenosine antagonists the most resistant to striatal dopamine depletion. When considering long-term treatment with adenosine antagonists concomitant administration of dopamine agonists might be required in order to obtain strong motor effects (cross-sensitization) and to avoid the development of telerance. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:38:17