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Titolo:
Dopamine signaling in Caenorhabditis elegans - Potential for parkinsonism research
Autore:
Wintle, RF; Van Tol, HHM;
Indirizzi:
Ctr Addict & Mental Hlth, Mol Neurobiol Lab, Toronto, ON, Canada Ctr Addict & Mental Hlth Toronto ON Canada biol Lab, Toronto, ON, Canada Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 d Sci, Toronto, ON M5S 1A1, Canada Univ Toronto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto Toronto ONCanada onto, Dept Pharmacol, Toronto, ON, Canada Univ Toronto, Dept Psychiat, Toronto, ON, Canada Univ Toronto Toronto ON Canada ronto, Dept Psychiat, Toronto, ON, Canada
Titolo Testata:
PARKINSONISM & RELATED DISORDERS
fascicolo: 3, volume: 7, anno: 2001,
pagine: 177 - 183
SICI:
1353-8020(200107)7:3<177:DSICE->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-ELEGANS; FUNCTIONAL EXPRESSION; SEROTONIN RECEPTOR; GENE; MUTATIONS; NEURONS; G(O); IDENTIFICATION; EXCITATION; NEMATODES;
Keywords:
parkinsonism; dopamine; G protein coupled receptors; motor control; Caenorhabditis elegans;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Van Tol, HHM Ctr Addict & Mental Hlth, Mol Neurobiol Lab, Toronto, ON, Canada Ctr Addict & Mental Hlth Toronto ON Canada onto, ON, Canada
Citazione:
R.F. Wintle e H.H.M. Van Tol, "Dopamine signaling in Caenorhabditis elegans - Potential for parkinsonism research", PARKINS R D, 7(3), 2001, pp. 177-183

Abstract

The nematode Caenorhabditis elegans is an attractive model system for the study of many biological processes. It possesses a simple nervous system with known anatomy and connectivity, is conveniently and cheaply cultured in the laboratory, and is amenable to many genetic manipulations that are impossible in mammalian systems. The recent completion of the C. elegans genomesequence provides a rich resource of genomic and bioinformatic data to researchers in diverse fields. This organism, however, has been underexploitedin the studies of many basic processes related to nervous system function,neuropsychiatric disorders and neuromuscular function. Anatomical, biochemical, behavioral, pharmacological and genetic evidence accumulated to date strongly suggests that dopamine is used as a neurotransmitter by C. elegans, and that its effects are mediated through pathway(s) that share many features with those of mammals. DNA sequence analysis reveals genes highly homologous to those encoding mammalian dopamine receptors. Probably, C. eleganshas dopamine receptors that transduce environmental cues into behaviors, and these receptors pharmacologically most closely resemble the D2 family. Here we present a review of the current state of research into the dopamine system of the worm, focussing on its potential for use in the study of biological processes related to parkinsonism. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:00:32