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Titolo:
Studies toward the total synthesis of scyphostatin: First entry to the highly functionalized cyclohexenone segment
Autore:
Izuhara, T; Katoh, T;
Indirizzi:
Sagami Chem Res Ctr, Sagamihara, Kanagawa 2290012, Japan Sagami Chem Res Ctr Sagamihara Kanagawa Japan 2290012 gawa 2290012, Japan
Titolo Testata:
ORGANIC LETTERS
fascicolo: 11, volume: 3, anno: 2001,
pagine: 1653 - 1656
SICI:
1523-7060(20010531)3:11<1653:STTTSO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTRAL SPHINGOMYELINASE INHIBITOR; TRICHOPEZIZA-MOLLISSIMA; CONFIGURATION; DISCOMYCETE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, T Sagami Chem Res Ctr, 4-4-1 Nishiohnuma, Sagamihara, Kanagawa 2290012, Japan Sagami Chem Res Ctr 4-4-1 Nishiohnuma Sagamihara Kanagawa Japan 2290012
Citazione:
T. Izuhara e T. Katoh, "Studies toward the total synthesis of scyphostatin: First entry to the highly functionalized cyclohexenone segment", ORG LETT, 3(11), 2001, pp. 1653-1656

Abstract

[GRAPHICS]The cyclohexenone segment 2 of scyphostatin (1), a potent inhibitor of neutral sphingomyelinase, was synthesized in an enantioselective manner starting from the bromo ether 5 and D-serinal derivative 3. The synthetic method features a coupling reaction of 5 with 3 to construct the asymmetric quaternary carbon center and a stereospecific epoxide ring formation as the key steps.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 00:44:35