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Titolo:
Angiostatin gene therapy inhibits the growth of murine squamous cell carcinoma in vivo
Autore:
Matsumoto, G; Ohmi, Y; Shindo, J;
Indirizzi:
Kanagawa Dent Coll, Dept Oral Surg 1, Kanagawa 2388580, Japan Kanagawa Dent Coll Kanagawa Japan 2388580 urg 1, Kanagawa 2388580, Japan
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 4, volume: 37, anno: 2001,
pagine: 369 - 378
SICI:
1368-8375(200106)37:4<369:AGTITG>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL PROGENITOR CELLS; RECEPTOR TYROSINE KINASE; LEWIS-LUNG-CARCINOMA; FACTOR FAMILY; TUMOR-GROWTH; ANGIOGENESIS; CANCER; EXPRESSION; METASTASES; VEGF;
Keywords:
angiostatin; gene therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, G Kanagawa Dent Coll, Dept Oral Surg 1, 82 Inaoka, Kanagawa 2388580, Japan Kanagawa Dent Coll 82 Inaoka Kanagawa Japan 2388580 0, Japan
Citazione:
G. Matsumoto et al., "Angiostatin gene therapy inhibits the growth of murine squamous cell carcinoma in vivo", ORAL ONCOL, 37(4), 2001, pp. 369-378

Abstract

Tumor growth is an angiogenesis-dependent process and therapeutic strategies aimed at inhibiting angiogenesis are theoretically attractive. Angiostatin has been shown to potently inhibit endothelial proliferation in vitro and turner growth in vivo. We now show that a shift in the balance of tumor angiogenesis by gene transfer of a cDNA coding for mouse angiostatin into mouse squamous cell carcinoma NRS-1 and SCC-VII cells supresses tumor growth in vivo. The inhibition of an angiostatin-transfected tumor was accompaniedby a marked reduction in vascularity and the presence of many apoptotic tumor cells. However, transfected-angiostatin cDNA does not affect the expression of the vascular endothelial growth factor (VEGF) and VEGF-R2 in the vascular endothelium. The inhibition mechanisms of neovascularization may be mediated independent of VEGF:VEGF-R2 complex. Our data may provide a usefulapproach for human oral cancer therapy by gene therapy with angiostatin. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 18:45:12