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Titolo:
Synaptotagmin VII as a plasma membrane Ca2+ sensor in exocytosis
Autore:
Sugita, S; Han, WP; Butz, S; Liu, XR; Fernandez-Chacon, R; Lao, Y; Sudhof, TC;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Mol Genet, Ctr Basic Neurosci, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 , Ctr Basic Neurosci, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Howard Hughes Med Inst, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 ward Hughes Med Inst, Dallas, TX 75390 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 30, anno: 2001,
pagine: 459 - 473
SICI:
0896-6273(200105)30:2<459:SVAAPM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; SYNAPTIC VESICLE; CA2+-DEPENDENT EXOCYTOSIS; NEUROTRANSMITTER RELEASE; REGULATED EXOCYTOSIS; HIPPOCAMPAL SYNAPSES; TRANSMITTER RELEASE; CALCIUM SENSOR; PC12 CELLS; BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Sudhof, TC Univ Texas, SW Med Ctr, Dept Mol Genet, Ctr Basic Neurosci, 6000 Harry Hines Blvd,NA4-118, Dallas, TX 75390 USA Univ Texas 6000 Harry Hines Blvd,NA4-118 Dallas TX USA 75390 SA
Citazione:
S. Sugita et al., "Synaptotagmin VII as a plasma membrane Ca2+ sensor in exocytosis", NEURON, 30(2), 2001, pp. 459-473

Abstract

Synaptotagmins I and II are Ca2+ binding proteins of synaptic vesicles essential for fast Ca2+-triggered neurotransmitter release. However, central synapses and neuroendocrine cells lacking these synaptotagmins still exhibitCa2+-evoked exocytosis. We now propose that synaptotagmin VII functions asa plasma membrane Ca2+ sensor in synaptic exocytosis complementary to vesicular synaptotagmins. We show that alternatively spliced forms of synaptotagmin VII are expressed in a developmentally regulated pattern in brain and are concentrated in presynaptic active zones of central synapses. In neuroendocrine PC12 cells, the C(2)A and C2B domains of synaptotagmin VII are potent inhibitors of Ca2+-dependent exocytosis, but only when they bind Ca2+, Our data suggest that in synaptic vesicle exocytosis, distinct synaptotagmins function as independent Ca2+ sensors on the two fusion partners, the plasma membrane (synaptotagmin VII) versus synaptic vesicles (synaptotagmins Iand II).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:34:36