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Titolo:
Na+ action potentials in human photoreceptors
Autore:
Kawai, F; Horiguchi, M; Suzuki, H; Miyachi, E;
Indirizzi:
Fujita Hlth Univ, Sch Med, Dept Physiol, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 Dept Physiol, Aichi 4701192, Japan Fujita Hlth Univ, Sch Med, Dept Ophthalmol, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 pt Ophthalmol, Aichi 4701192, Japan
Titolo Testata:
NEURON
fascicolo: 2, volume: 30, anno: 2001,
pagine: 451 - 458
SICI:
0896-6273(200105)30:2<451:NAPIHP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-GATED CHANNELS; ROD PHOTORECEPTORS; BIPOLAR CELLS; CONE PHOTORECEPTORS; MAMMALIAN RETINA; GANGLION-CELLS; VISUAL TRANSDUCTION; SALAMANDER RETINA; INNER SEGMENTS; PRIMATE RETINA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Kawai, F Fujita Hlth Univ, Sch Med, Dept Physiol, Aichi 4701192, Japan Fujita Hlth Univ Aichi Japan 4701192 siol, Aichi 4701192, Japan
Citazione:
F. Kawai et al., "Na+ action potentials in human photoreceptors", NEURON, 30(2), 2001, pp. 451-458

Abstract

Mammalian photoreceptors are hyperpolarized by a light stimulus and are commonly thought to be nonspiking neurons. We used the whole-cell patch-clamptechnique on surgically excised human retina to examine whether human photoreceptors can elicit action potentials. We discovered that human rod photoreceptors express voltage-gated Na+ channels, and generate Na+ action potentials, in response to membrane depolarization from membrane potentials of -60 or -70 mV. Na+ spikes in human rods were elicited at the termination of a light response that hyperpolarized the potential well below -50 mV. This served to amplify the release of a neurotransmitter when a bright light is turned off, and thus selectively amplify the off response to the light signal.

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Documento generato il 04/12/20 alle ore 13:08:10