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Titolo:
Proprioceptor pathway development is dependent on MATH1
Autore:
Bermingham, NA; Hassan, BA; Wang, VY; Fernandez, M; Banfi, S; Bellen, HJ; Fritzsch, B; Zoghbi, HY;
Indirizzi:
Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 ghes Med Inst, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 gram Dev Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pediat, Houston, TX 77030 USA Telethon Inst Genet & Med, I-20132 Milan, Italy Telethon Inst Genet & MedMilan Italy I-20132 Med, I-20132 Milan, Italy Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA
Titolo Testata:
NEURON
fascicolo: 2, volume: 30, anno: 2001,
pagine: 411 - 422
SICI:
0896-6273(200105)30:2<411:PPDIDO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIM HOMEOBOX GENE; SPINAL-CORD; COMMISSURAL INTERNEURONS; NERVOUS-SYSTEM; ROOF PLATE; BOX GENES; EXPRESSION; NEURONS; CELLS; DROSOPHILA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Zoghbi, HY Baylor Coll Med, Howard Hughes Med Inst, 1 Baylor Plaza, Houston, TX 77030USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 TX 77030USA
Citazione:
N.A. Bermingham et al., "Proprioceptor pathway development is dependent on MATH1", NEURON, 30(2), 2001, pp. 411-422

Abstract

The proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic helix-loop-helix transcription factor Math1 is essential for the development of certain components of the proprioceptive pathway, Including inner-ear hair cells, cerebellar granule neurons,and the pontine nuclei. Here, we demonstrate that Math1 null embryos lack the D1 interneurons and that these interneurons give rise to a subset of proprioceptor interneurons and the spinocerebellar and cuneocerebellar tracts. We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1)and establish that Math1 governs the development of multiple components ofthe proprioceptive pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:48:35