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Titolo:
Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains
Autore:
Shao, CS; Stambrook, PJ; Tischfield, JA;
Indirizzi:
Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 enet, Piscataway, NJ 08854 USA Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH45267 USA Univ Cincinnati Cincinnati OH USA 45267 l & Anat, Cincinnati, OH45267 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 169 - 172
SICI:
1061-4036(200106)28:2<169:MRISBC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO LOSS; NEUROFIBROMATOSIS TYPE-1; HETEROZYGOUS MICE; ESCHERICHIA-COLI; CANCER; MAP; PREDISPOSITION; POLYMORPHISMS; DEPENDENCE; HOMOLOGY;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Shao, CS Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 cataway, NJ 08854 USA
Citazione:
C.S. Shao et al., "Mitotic recombination is suppressed by chromosomal divergence in hybrids of distantly related mouse strains", NAT GENET, 28(2), 2001, pp. 169-172

Abstract

Mitotic recombination occurs with high frequency in humans(1,2) and mice(3). It leads to loss of heterozygosity (LOH) at important gene loci and can cause disease(4-7). However, the genetic modulators of mitotic recombination are not well understood. As recombination depends on a high level of nucleotide sequence homology(8-12), we postulate that the frequency of somatic variants derived from mitotic recombination should be diminished in progenyfrom crosses between strains of mice in which nucleotide sequences have diverged. Here we report that mitotic recombination is suppressed, to variousdegrees in different tissues, in hybrids of distantly related mouse strains. Reintroduction of greater chromosomal homology by backcrossing restores mitotic recombination in offspring. Thus, chromosomal divergence inhibits mitotic recombination and, consequently, may act as a modifier of cancer susceptibility by limiting the rate of LOH. The suppression of mitotic recombination in some F-1 hybrids in which meiotic recombination persists indicates that these processes are differentially affected by chromosomal divergence.

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Documento generato il 31/03/20 alle ore 16:32:21