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Titolo:
Deregulated expression of c-Myc depletes epidermal stem cells
Autore:
Waikel, RL; Kawachi, Y; Waikel, PA; Wang, XJ; Roop, DR;
Indirizzi:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Dept Dermatol, Houston, TX 77030 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 165 - 168
SICI:
1061-4036(200106)28:2<165:DEOCDE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN KERATINOCYTE MIGRATION; DIFFERENTIATION; FIBRONECTIN; INTEGRIN; PROLIFERATION; MARKERS; DEATH; MICE;
Tipo documento:
Letter
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Roop, DR Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Biol, Houston, TX 77030 USA
Citazione:
R.L. Waikel et al., "Deregulated expression of c-Myc depletes epidermal stem cells", NAT GENET, 28(2), 2001, pp. 165-168

Abstract

The beta -catenin/TCF signaling pathway is essential for the maintenance of epithelial stem cells in the small intestine(1). c-Myc a downstream target of beta -catenin/TCF (ref. 2), can induce differentiation of epidermal stem cells in vitro(3). To determine the role of c-Myc in epidermal stem cells in vivo, we have targeted expression of human MYC2 to the hair follicles and the basal layer of mouse epidermis using a keratin 14 vector (K14,MYC2), Adult K14,MYC2 mice gradually lose their hair and develop spontaneous ulcerated lesions due to a severe impairment in wound healing; their keratinocytes show impaired migration in response to wounding. The expression of beta1 integrin, which is preferentially expressed in epidermal stem cells(4) is unusually low in the epidermis of K14.MYC2 mice. Label-retaining analysisto identify epidermal stem cells reveals a 75% reduction in the number of stem cells in 3-month-old K14.MYC2 mice, compared with wildtype mice. We conclude that deregulated expression of c-Myc in stem cells reduces beta1 integrin expression, which is essential to both keratinocyte migration and stem cell maintenance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:45:07