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Titolo:
Hypoxia and Lou Gehrig
Autore:
Skene, JHP; Cleveland, DW;
Indirizzi:
Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ DurhamNC USA 27710 d Ctr, Dept Neurobiol, Durham, NC 27710 USA Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 nc Res, La Jolla, CA 92093 USA
Titolo Testata:
NATURE GENETICS
fascicolo: 2, volume: 28, anno: 2001,
pagine: 107 - 108
SICI:
1061-4036(200106)28:2<107:HALG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; AMYOTROPHIC-LATERAL-SCLEROSIS; ANGIOGENESIS; MECHANISMS;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Skene, JHP Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 Neurobiol, Durham, NC 27710 USA
Citazione:
J.H.P. Skene e D.W. Cleveland, "Hypoxia and Lou Gehrig", NAT GENET, 28(2), 2001, pp. 107-108

Abstract

Selective death of motor neurons beginning in mid life is the hallmark of the most abundant motor-neuron disease of adults, amyotrophic lateral sclerosis (ALS). An unexpected insight into potential causes of the disorder is now provided by mice lacking the hypoxia response element of the promoter of the gene encoding the vascular endothelial cell growth factor (VEGF). This elicits age-dependent, selective degeneration of motor neurons, and indicates that a primary cause of ALS may be chronic deficits in VEGF-dependent vascular perfusion or a direct neurotrophic effect of VEGF on motor neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:52:23