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Titolo:
Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem
Autore:
Beguin, P; Nagashima, K; Gonoi, T; Shibasaki, T; Takahashi, K; Kashima, Y; Ozaki, N; Geering, T; Iwanaga, T; Seino, S;
Indirizzi:
Chiba Univ, Grad Sch Med, Dept Cellular & Mol Med, Chuo Ku, Chiba 2608670,Japan Chiba Univ Chiba Japan 2608670 r & Mol Med, Chuo Ku, Chiba 2608670,Japan Univ Lausanne, Inst Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1005 CH-1005 Lausanne, Switzerland Chiba Univ, Pathogen Fungi & Microbial Toxicoses Res Ctr, Chuo Ku, Chiba 2608673, Japan Chiba Univ Chiba Japan 2608673 es Res Ctr, Chuo Ku, Chiba 2608673, Japan Chiba Univ, Grad Sch Med, Dept Mol Immunol,CREST, Chuo Ku, Chiba 2608670, Japan Chiba Univ Chiba Japan 2608670 unol,CREST, Chuo Ku, Chiba 2608670, Japan Hokkaido Univ, Grad Sch Vet Med, Lab Anat, Sapporo, Hokkaido 0600818, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600818 oro, Hokkaido 0600818, Japan
Titolo Testata:
NATURE
fascicolo: 6838, volume: 411, anno: 2001,
pagine: 701 - 706
SICI:
0028-0836(200106)411:6838<701:ROCCEA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAS-LIKE GTPASE; CALCIUM CHANNELS; BETA-SUBUNIT; FUNCTIONAL-CHARACTERIZATION; N-TYPE; FACILITATION; BINDING; ROLES; ACTIVATION; SIGNAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Seino, S Chiba Univ, Grad Sch Med, Dept Cellular & Mol Med, Chuo Ku, 1-8-1Inohana,Chiba 2608670, Japan Chiba Univ 1-8-1 Inohana Chiba Japan 2608670hiba 2608670, Japan
Citazione:
P. Beguin et al., "Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem", NATURE, 411(6838), 2001, pp. 701-706

Abstract

Voltage-dependent calcium (Ca2+) channels are involved in many specializedcellular functions(1-3), and are controlled by intracellular signals such as heterotrimeric G-proteins(4), protein kinases(5,6) and calmodulin (CaM)(7,8). However, the direct role of small G-proteins in the regulation of Ca2 channels is unclear. We report here that the GTP-bound form of kir/Gem, identified originally as a Ras-related small G-protein that binds CaM9-11, inhibits high-voltage-activated Ca2+ channel activities by interacting directly with the beta -subunit. The reduced channel activities are due to a decrease in alpha (1)-subunit expression at the plasma membrane. The binding of Ca2+/CaM to kir/Gem is required for this inhibitory effect by promoting the cytoplasmic localization of kir/Gem. Inhibition of L-type Ca2+ channels by kir/Gem prevents Ca2+ triggered exocytosis in hormone-secreting cells. We propose that the small G-protein kir/Gem, interacting with beta -subunits, regulates Ca2+ channel expression at the cell surface.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 09:39:49