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Titolo:
alpha(v)beta(3) integrin-mediated adenoviral transfer of interleukin-12 atthe periphery of hepatic colon cancer metastases induces VCAM-1 expressionand T-cell recruitment
Autore:
Mazzolini, G; Narvaiza, I; Bustos, M; Duarte, M; Tirapu, I; Bilbao, R; Qian, C; Prieto, J; Melero, I;
Indirizzi:
Univ Navarra, Sch Med, Dept Med, Gene Therapy Unit, E-31008 Pamplona, Spain Univ Navarra Pamplona Spain E-31008 herapy Unit, E-31008 Pamplona, Spain
Titolo Testata:
MOLECULAR THERAPY
fascicolo: 5, volume: 3, anno: 2001,
parte:, 1
pagine: 665 - 672
SICI:
1525-0016(200105)3:5<665:AIATOI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-INDUCIBLE PROTEIN-10; ANGIOGENESIS IN-VIVO; DIRECT INTRATUMORAL INJECTION; FACILITATE TUMOR-REGRESSION; ANTITUMOR IMMUNITY; GENE-TRANSFER; ESTABLISHED TUMORS; CD40 LIGAND; THERAPY; INDUCTION;
Keywords:
gene therapy; alpha(v)beta(3) (CD51/CD61); adenovirus; VCAM-1 (CD106); interleukin-12; adoptive T-cell therapy; immunotherapy; colon cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Melero, I Univ Navarra, Dept Med Interna, C-Irunlarrea 1, E-31008 Pamplona, Spain Univ Navarra C-Irunlarrea 1 Pamplona Spain E-31008 plona, Spain
Citazione:
G. Mazzolini et al., "alpha(v)beta(3) integrin-mediated adenoviral transfer of interleukin-12 atthe periphery of hepatic colon cancer metastases induces VCAM-1 expressionand T-cell recruitment", MOL THER, 3(5), 2001, pp. 665-672

Abstract

We previously reported that systemic injection of recombinant adenovirus resulted in a rim of gene transduction around experimental liver tumor nodules. This zone of higher infection is dependent on the cu,P, integrin, acting as an adenovirus internalization receptor, which is overexpressed in tissues surrounding liver metastases. When a recombinant adenovirus encoding interleukin-12 (AdCMVIL-12) is given into a subcutaneous tumor nodule in micealso bearing concomitant liver tumors, a fraction of AdCMVIL-12 reaches the systemic circulation and infects liver tissue, especially at the malignant/healthy tissue interface. As a result of the expression at this location of the interleukin-12 transgenes, VCAM-1 is induced on vessel cells and mediates the recruitment of adoptively transferred anti-tumor cytolytic T-lymphocytes. These studies provide mechanistic explanations for the potent therapeutic synergy observed between interleukin-12 gene transfer and adoptive T-cell therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 03:14:30