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Titolo:
Two-component diffusion tenser MRI of isolated perfused hearts
Autore:
Hsu, EW; Buckley, DL; Bui, JD; Blackband, SJ; Forder, JR;
Indirizzi:
Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA Duke Univ Durham NC USA27708 niv, Dept Biomed Engn, Durham, NC 27708 USA Duke Univ, Med Ctr, Ctr Vivo Microscopy, Durham, NC USA Duke Univ Durham NC USA iv, Med Ctr, Ctr Vivo Microscopy, Durham, NC USA Univ Florida, Dept Neurosci, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Neurosci, Gainesville, FL 32610 USA Univ Florida, Dept Physiol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Physiol, Gainesville, FL 32610 USA Univ Florida, Florida Brain Inst, Gainesville, FL USA Univ Florida Gainesville FL USA Florida Brain Inst, Gainesville, FL USA Natl High Magnet Field Lab, Tallahassee, FL USA Natl High Magnet Field Lab Tallahassee FL USA d Lab, Tallahassee, FL USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 6, volume: 45, anno: 2001,
pagine: 1039 - 1045
SICI:
0740-3194(200106)45:6<1039:TDTMOI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE; WATER DIFFUSION; HIPPOCAMPAL SLICE; FIBER ORIENTATION; NMR MICROSCOPY; SELF-DIFFUSION; RAT; ANISOTROPY; MYOCARDIUM; TISSUE;
Keywords:
biexponential decay; fiber orientation mapping; myocardial microstructure; compartmental analysis; anisotropic diffusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Hsu, EW Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA Duke Univ Durham NC USA 27708 t Biomed Engn, Durham, NC 27708 USA
Citazione:
E.W. Hsu et al., "Two-component diffusion tenser MRI of isolated perfused hearts", MAGN RES M, 45(6), 2001, pp. 1039-1045

Abstract

Nonmonoexponential MR diffusion decay behavior has been observed at high diffusion-weighting strengths for cell aggregates and tissues, including themyocardium; however, implications for myocardial MR diffusion tenser imaging are largely unknown. In this study, a slow-exchange-limit, two-componentdiffusion tenser model was fitted to diffusion-weighted images obtained inisolated, perfused rat hearts. Results indicate that there are at least two distinct components of anisotropic diffusion, characterized by a "fast" component whose principal diffusivity is comparable to that of the perfusate, and a highly anisotropic "slow" component. It is speculated that the two components correspond to tissue compartments and have a general agreement with the orientations of anisotropy, or fiber orientations, in the myocardium. Moreover, consideration of previous studies of myocardial diffusion suggests that the presently observed fast component may likely be dominated by diffusion in the vascular space, whereas the slow component may include theintracellular and interstitial compartments. The implications of the results for myocardial fiber orientation mapping and limitations of the current two-component model used are also discussed. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:22:08