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Titolo:
Dynamic contrast-enhanced MRI using Gd-DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors
Autore:
Port, RE; Knopp, MV; Brix, G;
Indirizzi:
German Canc Res Ctr, D-69009 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-69009 69009 Heidelberg, Germany Fed Off Radiat Protect, Dept Med Radiat Hyg, Neuherberg, Germany Fed Off Radiat Protect Neuherberg Germany diat Hyg, Neuherberg, Germany
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 6, volume: 45, anno: 2001,
pagine: 1030 - 1038
SICI:
0740-3194(200106)45:6<1030:DCMUGI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-BARRIER PERMEABILITY; BREAST-TUMORS; WATER DIFFUSION; GADOLINIUM-DTPA; BLOOD; PHARMACOKINETICS; MODEL; TRACER; TISSUE; PARAMETERS;
Keywords:
dynamic contrast-enhanced MRI; Gd-DTPA; breast cancer; NONMEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Port, RE German Canc Res Ctr, D-0200,POB 10 19 49, D-69009 Heidelberg, Germany German Canc Res Ctr D-0200,POB 10 19 49 Heidelberg Germany D-69009
Citazione:
R.E. Port et al., "Dynamic contrast-enhanced MRI using Gd-DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors", MAGN RES M, 45(6), 2001, pp. 1030-1038

Abstract

Gd-DTPA kinetics in arterial brood was investigated by dynamic MRI in 47 patients with malignant and benign mammary tumors. Signal enhancement was monitored for 10 min after the beginning of a 1-min infusion of 0.1 mmol/kg Gd-DTPA. Kinetics in blood was biexponential with median half-lives of 21 sec and 11.1 min, respectively. Peak signal enhancement and the area under the signal enhancement-time curve varied 2,5- and 3.7-fold between patients. The shortest mean residence time in one of up to three tumor compartments, MRT*, was estimated using either the individual (reference) or a mean population (surrogate) arterial input function (AIF). MRT* (reference estimate) was 1.0 (0-1.5), 1.9 (1.5-2.3), and 2.5 (2.3-2.8) min in carcinomas, fibroadenomas, and mastopathies, respectively (median and interquartile distance). Surrogate estimates were unbiased but differed from the reference estimates 1.5-fold or more in 23% of cases. AIFs should be monitored individually if accurate estimates of individual MRT* are desired. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:21:07