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Titolo:
Immunohistochemical detection of hormones in rat pituitary adenomas following fractionated irradiation.
Autore:
Bartel-Friedrich, S; Saeger, W; Friedrich, RE; Laas, R;
Indirizzi:
Univ Halle Wittenberg, Klin & Poliklin Hals Nasen & Ohrenheilkunde Kopf, D-06097 Halle, Germany Univ Halle Wittenberg Halle Germany D-06097 Kopf, D-06097 Halle, Germany
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 5, volume: 80, anno: 2001,
pagine: 257 - 262
SICI:
1615-0007(200105)80:5<257:IDOHIR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
GER
Soggetto:
SPRAGUE-DAWLEY RATS; SPONTANEOUS NEOPLASMS; SPONTANEOUS TUMORS; MANDIBULAR GLAND; WISTAR RATS; RADIATION;
Keywords:
pituitary tumours; irradiation adverse effects; radiation-induced adenoma; pituitary hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Bartel-Friedrich, S Univ Halle Wittenberg, Klin & Poliklin Hals Nasen & Ohrenheilkunde Kopf, Magdeburger Str 12, D-06097 Halle, Germany Univ Halle Wittenberg Magdeburger Str 12 Halle Germany D-06097
Citazione:
S. Bartel-Friedrich et al., "Immunohistochemical detection of hormones in rat pituitary adenomas following fractionated irradiation.", LARY RH OTO, 80(5), 2001, pp. 257-262

Abstract

Background: The aim of this study was to determine the hormones produced in pituitary gland tumours (TM) following fractionated external irradiation in rats. The TM arose in the course of studies on other questions of radiation effects. Methods: The left neck and skull base of sixty female Wistar rats, 3 to 4 months of age at the beginning of the external irradiation, were subjected to roentgen rays exposure, fractionated to 2 Grays daily, either up to 20, 40 or 60 Cy. The midline of the neck and skull was always inside the radiation field. The animals were sacrificed either 6 months or 12 months after completion of the randomly assigned irradiation protocol. Five non-irradiated rats served as controls. Results: No TM developed in the non-irradiated animals. Out of 60 irradiated rats 9 developed a pituitary TM (15%). In remnants of the normal adenohypophysis we revealed immunohistochemical reactivity for growth hormone (GH), adrenocorticotropic hormone (ACTH),prolactin (PRL), thyroid stimulating hormone (TSH), and follicle stimulating hormone (FSH). In the radiation-induced adenomas, 4 TM were immunoreactive for TSH, 4 for GH, 2 for PRL, and 2 for FSH. The TM did not react with anti-ACTH and anti-LH (luteinizing hormone) antisera. Conclusions: Obviously, irradiation accelerates the development of pituitary gland adenomas. In this series the TM were predominantly incidental findings at necropsies after pretermed follow-up intervals with a variety of hormone-producing cells. On the other hand, four of nine TM were null adenomas. Necropsies of the brain should be carried out routinely in irradiation studies of the skull.

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Documento generato il 20/01/20 alle ore 07:33:46