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Titolo:
Humoral immune response to inner ear proteins in patients with sensorineural hearing loss.
Autore:
Naumann, A; Hempel, JM; Schorn, K;
Indirizzi:
Univ Munich, Klinikum Grosshadern, Klin & Poliklin Hals Nasen & Ohrenkranke, D-81377 Munich, Germany Univ Munich Munich Germany D-81377 Ohrenkranke, D-81377 Munich, Germany
Titolo Testata:
LARYNGO-RHINO-OTOLOGIE
fascicolo: 5, volume: 80, anno: 2001,
pagine: 237 - 244
SICI:
1615-0007(200105)80:5<237:HIRTIE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
GER
Soggetto:
HEAT-SHOCK PROTEIN; HUMAN ENDOLYMPHATIC SAC; SERUM ANTIBODIES; MENIERES-DISEASE; AUTOIMMUNE; HEAT-SHOCK-PROTEIN-70; AUTOANTIBODIES; ANTIGEN;
Keywords:
immunoblot with inner ear antigens; heat shock protein 70; humoral immunoreactivity; progressive sensorineural hearing loss;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Naumann, A Univ Munich, Klinikum Grosshadern, Klin & Poliklin Hals Nasen &Ohrenkranke, Marchioninistr 15, D-81377 Munich, Germany Univ Munich Marchioninistr 15 Munich Germany D-81377 , Germany
Citazione:
A. Naumann et al., "Humoral immune response to inner ear proteins in patients with sensorineural hearing loss.", LARY RH OTO, 80(5), 2001, pp. 237-244

Abstract

Background: The precise mechanism of inner ear disease is still unknown. An autoimmune reaction could be one of several possible pathogenic factors involved in progressive sensorineural hearing loss. Heat shock protein 70 issuggested to play an important role in the development of autoimmune diseases. The aim of this study is the investigation of humoral immune reactivity to inner ear components in patients with sensorineural hearing loss. Methods: The presence of antibodies to inner ear components was determined by immune-blotting extracted bovine or human inner ear proteins. Study groups consisted of patients with idiopathic progressive sensorineural hearing loss(group A), patients with Meniere's disease (group B), patients with suddenhearing loss (group C), patients with otosclerosis (group D), patients with Cogan's disease (group E), and individuals without hearing problems (group F). Results: 40% of the patients with progressive sensorineural hearing loss showed reactivity against a 68-kDa protein extracted from bovine inner ear. In contrast to this, only 5% of healthy individuals and 10% with Meniere's disease showed reactivity against the 68-kDa protein from bovine innerear or against bovine heat shock protein 70. Some of the patients who showed reactivity against bovine inner ear proteins were tested with human inner ear and human heat shock protein 70; all of these showed reactivity. Approximately 6% of the patients with sudden hearing loss (group C), otosclerosis (group D), and Cogan's disease (group E) showed reactivity to inner ear proteins. A non-specific humoral immune reaction against inner ear proteinswith molecular weights of 30, 40, 50, 60, and 220 kDa was observed in all patients. Discussion: These results indicate a humoral immune reactivity against heat shock protein 70, which might be responsible for the pathogenesis of progressive sensorineural hearing loss.

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Documento generato il 18/02/20 alle ore 11:16:18