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Titolo:
The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-Independent mechanism
Autore:
Dosch, T; Horn, F; Schneider, G; Kratzer, F; Dobner, T; Hauber, J; Stauber, RH;
Indirizzi:
Univ Erlangen Nurnberg, Inst Clin & Mol Virol, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany Univ Regensburg Regensburg Germany D-93053 , D-93053 Regensburg, Germany
Titolo Testata:
JOURNAL OF VIROLOGY
fascicolo: 12, volume: 75, anno: 2001,
pagine: 5677 - 5683
SICI:
0022-538X(200106)75:12<5677:TAT5EO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE GENE-EXPRESSION; NUCLEAR EXPORT SIGNAL; EARLY REGION-4; LIVING CELLS; INTRACELLULAR TRAFFICKING; TUMOR-ANTIGEN; PROTEIN; REV; BINDING; RNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Stauber, RH Univ Erlangen Nurnberg, Inst Clin & Mol Virol, Schlossgarten 4, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Schlossgarten 4 Erlangen Germany D-91054
Citazione:
T. Dosch et al., "The adenovirus type 5 E1B-55K oncoprotein actively shuttles in virus-infected cells, whereas transport of E4orf6 is mediated by a CRM1-Independent mechanism", J VIROLOGY, 75(12), 2001, pp. 5677-5683

Abstract

The E1B-55K and E4orf6 proteins of adenovirus type 5 are involved in viralmRNA export. Here we demonstrate that adenovirus infection does not inhibit the function of the E1B-55K nuclear export signal and that E1B-55K also shuttles in infected cells, Even during virus infection, E1B-55K was exported by the leptomycin B-sensitive CRM1 pathway, whereas E4orf6 transport appeared to be mediated by an alternative mechanism. Our results strengthen thepotential role of E1B-55K as the "driving force" for adenoviral late mRNA export.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/06/20 alle ore 12:43:52