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Titolo:
Abnormally increased semantic priming in children with symptomatic HIV-1 disease: Evidence for impaired development of semantics?
Autore:
Brouwers, P; van Engelen, M; Lalonde, F; Perez, L; de Haan, E; Wolters, P; Martin, A;
Indirizzi:
NCI, HIV & AIDS Malignancy Branch, Bethesda, MD 20892 USA NCI Bethesda MDUSA 20892 AIDS Malignancy Branch, Bethesda, MD 20892 USA Univ Utrecht, Psychol Lab, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands NIMH, Lab Brain & Cognit, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 MH, Lab Brain & Cognit, Bethesda, MD 20892 USA Med Illness Counseling Ctr, Chevy Chase, MD USA Med Illness Counseling Ctr Chevy Chase MD USA g Ctr, Chevy Chase, MD USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 4, volume: 7, anno: 2001,
pagine: 491 - 501
SICI:
1355-6177(200105)7:4<491:AISPIC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CENTRAL-NERVOUS-SYSTEM; QUINOLINIC ACID; CEREBROSPINAL-FLUID; BASAL GANGLIA; NEUROLOGIC MANIFESTATIONS; ALZHEIMERS-DISEASE; PEDIATRIC AIDS; INFECTION; KNOWLEDGE;
Keywords:
HIV-1; AIDS; neuropsychological tests; pediatrics; reaction times; semantic development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Brouwers, P Baylor Coll Med, Texas Childrens Canc Ctr, 6621 Fannin St,MC 3-3320, Houston, TX 77030 USA Baylor Coll Med 6621 Fannin St,MC 3-3320 Houston TX USA 77030
Citazione:
P. Brouwers et al., "Abnormally increased semantic priming in children with symptomatic HIV-1 disease: Evidence for impaired development of semantics?", J INT NEURO, 7(4), 2001, pp. 491-501

Abstract

Language deficits are a major characteristic of neurobehavioral dysfunction in pediatric HIV disease. An object decision task, which assessed reaction time facilitation following a semantic or identical prime in comparison to an unrelated prime, was used to investigate whether semantic processing abnormalities could be responsible, in part, for these deficits. Thirty children with vertically acquired HIV infection (M age 9.0 years; range 6-13) participated. Either a picture of the same object (repetition prime), a semantically related object (semantic prime), a semantically unrelated object, or a nonsense object preceded a target picture, which in 50% of the cases was a real object. Brain scans of children were rated and used together withneurobehavioral functioning to classify children as having HIV-related CNSabnormalities (n = 13) or not (n = 17). increased semantic priming but notrepetition priming was associated with a greater degree of cortical atrophy. Furthermore, CNS compromised children had significantly faster reaction times following a semantic prime compared to an unrelated prime than non-compromised patients. This facilitation following semantic priming for the CNS compromised patients (13.3%) almost equaled the facilitation following repetition priming (15.3%) while for the non-compromised patients facilitation following semantic priming (7.9%) was clearly smaller than following repetition priming (14.6%). These data suggest that HIV infection in children may result in a reduced neural network leading to impoverished semantic representations characterized by poor differentiation between closely related objects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 02:08:53