Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Circulating levels of plasminogen activator inhibitor type-1, tissue plasminogen activator, and thrombomodulin in hemodialysis patients: Biochemical correlations and role as independent predictors of coronary artery stenosis
Autore:
Segarra, A; Chacon, P; Martinez-Eyarre, C; Argelaguer, XV; Vila, J; Ruiz, P; Fort, J; Bartolome, J; Camps, J; Moliner, E; Pelegri, A; Marco, F; Olmos, A; Piera, L;
Indirizzi:
Hosp Gen Valle Hebron, Serv Nefrol, Unidad Invest, E-08035 Barcelona, Spain Hosp Gen Valle Hebron Barcelona Spain E-08035 , E-08035 Barcelona, Spain Hosp Gen Valle Hebron, Serv Bioquim, E-08035 Barcelona, Spain Hosp Gen Valle Hebron Barcelona Spain E-08035 , E-08035 Barcelona, Spain Ctr Dialisis Nephros, Barcelona, Spain Ctr Dialisis Nephros Barcelona Spain Dialisis Nephros, Barcelona, Spain
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
fascicolo: 6, volume: 12, anno: 2001,
pagine: 1255 - 1263
SICI:
1046-6673(200106)12:6<1255:CLOPAI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIOVASCULAR RISK-FACTORS; ISCHEMIC-HEART-DISEASE; CHRONIC-RENAL-FAILURE; ENDOTHELIAL-CELL MARKERS; C-REACTIVE PROTEIN; CHRONIC UREMIA; COAGULATION-FIBRINOLYSIS; MAINTENANCE HEMODIALYSIS; DIALYSIS PATIENTS; ANGINA-PECTORIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Segarra, A Hosp Gen Valle Hebron, Serv Nefrol, Unidad Invest, Passeig VallHebron 119-129, E-08035 Barcelona, Spain Hosp Gen Valle Hebron Passeig Vall Hebron 119-129 Barcelona Spain E-08035
Citazione:
A. Segarra et al., "Circulating levels of plasminogen activator inhibitor type-1, tissue plasminogen activator, and thrombomodulin in hemodialysis patients: Biochemical correlations and role as independent predictors of coronary artery stenosis", J AM S NEPH, 12(6), 2001, pp. 1255-1263

Abstract

This study investigated the relationship between the circulating levels ofthe endothelial cell glycoproteins plasminogen activator inhibitor type 1 (PAI-1), tissue plasminogen activator (TPA), and thrombomodulin (TM) and the major vascular risk factors described in dialysis patients. In addition, the role of these endothelial cell products as independent predictors of coronary artery disease (CAD) was analyzed. Levels of TM, TPA antigen (Ag), TPA activity, PAI-1 Ag, PAI-1 activity, TPA/PAI complexes, thrombin-antithrombin complexes, fibrinopeptide A, C-reactive protein (CRP), interleukin-1 beta and tumor necrosis factor-alpha, lipids, apoproteins A1 and B, and albumin were measured in a group of 200 nondiabetic dialysis patients and 100 healthy matched volunteers. When compared with healthy controls, dialysis patients showed increased levels of CRP, TM, TPA, and PAI-1 and evidence of increased thrombin-dependent fibrin formation. Increased levels of active PAI-1 were associated to a great extent with major classic vascular risk factors and to a lesser extent with CRP and serum triglycerides. Forty-six patients (23%) had evidence of CAD. Variables associated with CAD in the univariate analysis included age, time on dialysis, male gender, number of packs of cigarettes per year, high BP, fibrinogen, apolipoprotein B, albumin, PAI-1 activity, CRP, thrombin-antithrombin complexes, and fibrinopeptide A. Logistic regression analysis found age, high-density lipoprotein cholesterol,gender, high BP, CRP, time on dialysis, and PAI-1 activity to be independent predictors of CAD. This model classified correctly 85% of patients as having CAD and showed adequate goodness of fit for all risk categories. Our data support a pathogenic link among activated inflammatory response, endothelial injury, and CAD in hemodialysis patients and suggest that assessment of circulating PAI-1 levels could be an additional tool to identify dialysis patients who are at risk for developing atheromatous cardiovascular disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:34:32