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Titolo:
Serum carotenoids and cerebral white matter lesions: The Rotterdam Scan Study
Autore:
den Heijer, T; Launer, LJ; de Groot, JG; de Leeuw, FE; Oudkerk, M; van Gijn, J; Hofman, A; Breteler, MMB;
Indirizzi:
Erasmus Med Ctr, Dept Epidemiol & Biostat, Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands & Biostat, Rotterdam, Netherlands Netherlands Inst Hlth Sci, NIHES, Rotterdam, Netherlands Netherlands Inst Hlth Sci Rotterdam Netherlands Rotterdam, Netherlands Univ Utrecht, Med Ctr, Dept Neurol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands Ctr, Dept Neurol, Utrecht, Netherlands Erasmus Med Ctr, Dr Daniel Den Hoed Canc Ctr, Dept Radiol, Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands pt Radiol, Rotterdam, Netherlands
Titolo Testata:
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
fascicolo: 5, volume: 49, anno: 2001,
pagine: 642 - 646
SICI:
0002-8614(200105)49:5<642:SCACWM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUSTRIAN STROKE PREVENTION; LOW-DENSITY-LIPOPROTEIN; VASCULAR RISK-FACTORS; CAROTID ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; COGNITIVE FUNCTION; ALPHA-TOCOPHEROL; PLASMA; HYPERINTENSITIES; ANTIOXIDANTS;
Keywords:
leukoaraiosis; magnetic resonance imaging; carotenoids; antioxidant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Breteler, MMB Erasmus Univ, Dept Epidemiol & Biostat, POB 1738, NL-3000 DRRotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR ands
Citazione:
T. den Heijer et al., "Serum carotenoids and cerebral white matter lesions: The Rotterdam Scan Study", J AM GER SO, 49(5), 2001, pp. 642-646

Abstract

OBJECTIVES: To study the relation between serum levels of carotenoids and white matter lesions (WMLs) on magnetic resonance imaging (MRI). DESIGN: Evaluation of cross-sectional data from a cohort study. SETTING: The Rotterdam Scan Study. PARTICIPANTS: Two hundred and three nondemented older persons, age 60 to 90, from the Rotterdam Scan Study. MEASUREMENTS: Serum levels of carotenoids were determined. WMLs on MRIs were rated separately into periventricular and subcortical WMLs. Odds ratios (ORs) for the presence of severe WMLs (upper decile) were calculated per standard deviation (SD) increase in serum carotenoid level and per SD increase in overall carotenoid serum level. Effect modification by smoking status was studied through stratified analyses. RESULTS: Increasing levels of all the separate carotenoids were associatedwith less severe periventricular WMLs, which reached statistical significance for the overall carotenoid serum level (OR 0.4 per SD; 95% confidence interval (CI) = 0.2-0.9). We found no association between carotenoid levels and the presence of severe subcortical WMLs (OR 1.2 per SD; 95% CI = 0.7-2.0). The association of carotenoid levels with severe periventricular WMLs was more marked in those who ever smoked (OR 0.1 per SD; 95% CI = 0.0-0.9) than in those who had never smoked (OR 0.9 per SD; 95% CI = 0.4-2.1). CONCLUSIONS: These findings are compatible with the view that high levels of carotenoids may protect against WMLs in the periventricular region, in particular in smokers. Longitudinal studies with repeated measurements of both carotenoids and WMLs are necessary to explore this hypothesis further.

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Documento generato il 09/07/20 alle ore 18:05:33