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Titolo:
Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge
Autore:
Grzella, I; Muller, BW; Oades, RD; Bender, S; Schall, U; Zerbin, D; Wolstein, J; Sartory, G;
Indirizzi:
Univ Clin Essen, Clin Psychiat & Psychotherapy, D-45147 Essen, Germany Univ Clin Essen Essen Germany D-45147 chotherapy, D-45147 Essen, Germany Aachen Tech Univ, Clin Child & Adolescent Psychiat & Psychotherapy, Aachen, Germany Aachen Tech Univ Aachen Germany ychiat & Psychotherapy, Aachen, Germany Univ Clin Essen, Clin Child & Adolescent Psychiat & Psychotherapy, Essen, Germany Univ Clin Essen Essen Germany Psychiat & Psychotherapy, Essen, Germany Univ Newcastle, Discipline Psychiat, Callaghan, NSW, Australia Univ Newcastle Callaghan NSW Australia ychiat, Callaghan, NSW, Australia Univ Wuppertal, Wuppertal, Germany Univ Wuppertal Wuppertal GermanyUniv Wuppertal, Wuppertal, Germany
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 3, volume: 26, anno: 2001,
pagine: 235 - 246
SICI:
1180-4882(200105)26:3<235:NMNIPW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; OBSESSIVE-COMPULSIVE DISORDER; AUDITORY SENSORY MEMORY; STIMULUS DEVIANCE; MAGNETOENCEPHALOGRAPHIC RECORDINGS; ATTENTIONAL MODULATION; HEALTHY-SUBJECTS; MMN GENERATION; DYSFUNCTION; CORTEX;
Keywords:
acoustic stimulation; electroencephalography; evoked potentials; auditory; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, BW Univ Clin Essen, Clin Psychiat & Psychotherapy, Virchowstr 174,D-45147 Essen, Germany Univ Clin Essen Virchowstr 174 Essen Germany D-45147 , Germany
Citazione:
I. Grzella et al., "Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge", J PSYCH NEU, 26(3), 2001, pp. 235-246

Abstract

Objective: Given recent reports of differences between mismatch negativity(MMN) elicited by always novel sounds (novelty-elicited MMN) and that elicited by repeated rare deviants (conventional MMN), we investigated novelty-elicited MMN and P3a in patients with schizophrenia before and after a nonstandardized inpatient treatment. Design: Electrophysiological and clinical assessment of patients on admission and discharge from hospital. Assessmentof control subjects on 2 sessions. Setting: Inpatient treatment in a psychiatric university hospital. Subjects: 20 patients with schizophrenia and 21healthy control subjects of similar age and sex. Selection of patients with first- to third-episode schizophrenia. Outcome measures: Early and late component MMN amplitudes and latencies, P3a amplitudes and latencies, Positive and Negative Syndrome Scale (PANSS), Global Assessment of Functioning (GAF), Extrapyramidal Symptom Scale (EPS), Abnormal Involuntary Movement Scale (AIMS) and chlorpromazine equivalents. Results: In patients with schizophrenia, novelty-elicited MMN was unimpaired on admission, and there was a statistically significant reduction of the late MMN component with treatment. Improvements in symptom expression were associated with increased latencies of the early MMN component. Conclusion: Results indicate differences in information processing between conventional and novelty-elicited MMN. Some components of the novelty-elicited MMN might be more state dependent than those of the conventional MMN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:47:31