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Titolo:
Apomorphine and the dopamine hypothesis of schizophrenia: a dilemma?
Autore:
Depatie, L; Lal, S;
Indirizzi:
McGill Univ, Douglas Hosp, Dept Psychiat, Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ Verdun PQ Canada H4H 1R3 Res Ctr, Verdun, PQ H4H 1R3, Canada McGill Univ, Dept Psychiat, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Univ, Dept Psychiat, Montreal, PQ, Canada Montreal Gen Hosp, Dept Psychiat, Montreal, PQ H3G 1A4, Canada Montreal Gen Hosp Montreal PQ Canada H3G 1A4 Montreal, PQ H3G 1A4, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 3, volume: 26, anno: 2001,
pagine: 203 - 220
SICI:
1180-4882(200105)26:3<203:AATDHO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETION; LOW-DOSE APOMORPHINE; LONG-TERM TREATMENT; PARKINSONS-DISEASE; SUBCUTANEOUS APOMORPHINE; MOTOR FLUCTUATIONS; ANTIPSYCHOTIC-DRUGS; RECEPTOR AGONIST; SUBLINGUAL APOMORPHINE; PROLACTIN SECRETION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
149
Recensione:
Indirizzi per estratti:
Indirizzo: Lal, S McGill Univ, Douglas Hosp, Dept Psychiat, Res Ctr, 6875 LaSalle Blvd, Verdun, PQ H4H 1R3, Canada McGill Univ 6875 LaSalle Blvd Verdun PQ Canada H4H 1R3 1R3, Canada
Citazione:
L. Depatie e S. Lal, "Apomorphine and the dopamine hypothesis of schizophrenia: a dilemma?", J PSYCH NEU, 26(3), 2001, pp. 203-220

Abstract

The dopamine (DA) hypothesis of schizophrenia implicates an enhancement ofDA function in the pathophysiology of the disorder, at least in the genesis of positive symptoms. Accordingly, apomorphine, a directly acting DA receptor agonist, should display psychotomimetic properties. A review of the literature shows little or no evidence that apomorphine, in doses that stimulate postsynaptic DA receptors, induces psychosis in nonschizophrenic subjects or a relapse or exacerbation of psychotic symptoms in patients with schizophrenia. After a detailed review of the literature reporting psychotogenic effects of apomorphine in patients with Parkinson's disease, an interpretation of these data is difficult, in part because of several confounding factors, such as the concomitant use of drugs known to induce psychosis and the advanced state of the progressive neurological disorder. In the context of the DA hypothesis of schizophrenia, the limited ability of apomorphine to induce psychosis, in contrast to indirectly acting DA agonists that increase synaptic DA, may be explained by the relatively weak affinity of apomorphine for the D, receptor compared with DA. Alternatively, enhancement of DA function, though necessary, may be insufficient by itself to induce psychosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:08:30