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Titolo:
Toward an integrative understanding of social phobia
Autore:
Li, D; Chokka, P; Tibbo, P;
Indirizzi:
Univ Alberta Hosp, Dept Psychiat, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp Edmonton AB Canada T6G 2B7 Edmonton, AB T6G 2B7, Canada Grey Nuns Community Hosp & Hlth Ctr, Edmonton, AB, Canada Grey Nuns Community Hosp & Hlth Ctr Edmonton AB Canada onton, AB, Canada
Titolo Testata:
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
fascicolo: 3, volume: 26, anno: 2001,
pagine: 190 - 202
SICI:
1180-4882(200105)26:3<190:TAIUOS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; OBSESSIVE-COMPULSIVE DISORDER; HUMAN PERSONALITY-TRAIT; DIRECT-INTERVIEW FAMILY; DOPAMINE-RECEPTOR GENE; VENTRAL TEGMENTAL AREA; EXON-III POLYMORPHISM; URINARY FREE CORTISOL; NOVELTY SEEKING; ANXIETY DISORDERS;
Keywords:
anxiety; dopamine; GABA; genetics; neurobiology; norepinephrine; phobic disorders; serotonin;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
117
Recensione:
Indirizzi per estratti:
Indirizzo: Li, D Univ Alberta Hosp, Dept Psychiat, 1E7-36 Walter McKenzie Ctr,8440-112 St, Edmonton, AB T6G 2B7, Canada Univ Alberta Hosp 1E7-36 Walter McKenzieCtr,8440-112 St Edmonton AB Canada T6G 2B7
Citazione:
D. Li et al., "Toward an integrative understanding of social phobia", J PSYCH NEU, 26(3), 2001, pp. 190-202

Abstract

Our objective was to examine the neurobiology of social phobia from the perspectives of basic sciences, genetics, immunology, neuroendocrinology, neurotransmission and neuroimaging and to provide an integrated understanding of social phobia in the framework of a hypothetical neural circuit. Family and twin studies provide evidence that social phobia is heritable with significant genetic influence, and molecular genetics offers possibilities in understanding the nature of the trait that is transmitted. The biologic distinctiveness of social phobia from anxiety disorders and physiological validation of differences between generalized and discrete social phobia subtypes have been implicated in genetic, naturalistic and chemical challenge studies. Evidence of specific dysfunction of dopaminergic, serotonergic, noradrenergic and GABAergic (gamma -aminobutyric acid) neurotransmitter systems has been presented in animal models, challenge studies and treatment investigations. Preliminary neuroimaging research supports previous studies suggesting striatal dopaminergic dysfunction in social phobia and suggests the importance of functional circuits. A neural circuit involving the striatum, thalamus, amygdala and cortical structures may provide a framework for integrating much of the current knowledge on the neurobiology of social phobia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/07/18 alle ore 03:56:25